Correlation between reported dengue illness history and seropositivity in rural Thailand.
In the latest World Health Organization (WHO) recommendation for Dengvaxia implementation, either serological testing or a person's history of prior dengue illness may be used as supporting evidence to identify dengue virus (DENV)-immune individuals eligible for vaccination, in areas with limit...
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2021
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oai:doaj.org-article:4a2efcfedd9c4ca78dccf8993dc38a162021-11-25T06:31:46ZCorrelation between reported dengue illness history and seropositivity in rural Thailand.1935-27271935-273510.1371/journal.pntd.0009459https://doaj.org/article/4a2efcfedd9c4ca78dccf8993dc38a162021-06-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009459https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735In the latest World Health Organization (WHO) recommendation for Dengvaxia implementation, either serological testing or a person's history of prior dengue illness may be used as supporting evidence to identify dengue virus (DENV)-immune individuals eligible for vaccination, in areas with limited capacity for laboratory confirmation. This analysis aimed to estimate the concordance between self-reported dengue illness histories and seropositivity in a prospective cohort study for dengue virus infection in Kamphaeng Phet province, a dengue-endemic area in northern Thailand. The study enrolled 2,076 subjects from 516 multigenerational families, with a median age of 30.6 years (range 0-90 years). Individual and family member dengue illness histories were obtained by questionnaire. Seropositivity was defined based on hemagglutination inhibition (HAI) assays. Overall seropositivity for DENV was 86.5% among those aged 9-45 years, which increased with age. 18.5% of participants reported a history of dengue illness prior to enrollment; 30.1% reported a previous DENV infection in the family, and 40.1% reported DENV infection in either themselves or a family member. Relative to seropositivity by HAI in the vaccine candidate group, the sensitivity and specificity of individual prior dengue illness history were 18.5% and 81.6%, respectively; sensitivity and specificity of reported dengue illness in a family member were 29.8% and 68.0%, and of either the individual or a family member were 40.1% and 60.5%. Notably, 13.4% of individuals reporting prior dengue illness were seronegative. Given the high occurrence of asymptomatic and mild DENV infection, self-reported dengue illness history is poorly sensitive for prior exposure and may misclassify individuals as 'exposed' when they were not. This analysis highlights that a simple, highly sensitive, and highly specific test for determining serostatus prior to Dengvaxia vaccination is urgently needed.Darunee BuddhariKathryn B AndersonGregory D GromowskiRichard G JarmanSopon IamsirithawornButsaya ThaisomboonsukTaweewun HunsawongAnon SrikiatkhachornAlan L RothmanAnthony R JonesStefan FernandezStephen J ThomasTimothy P EndyPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0009459 (2021) |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Darunee Buddhari Kathryn B Anderson Gregory D Gromowski Richard G Jarman Sopon Iamsirithaworn Butsaya Thaisomboonsuk Taweewun Hunsawong Anon Srikiatkhachorn Alan L Rothman Anthony R Jones Stefan Fernandez Stephen J Thomas Timothy P Endy Correlation between reported dengue illness history and seropositivity in rural Thailand. |
| description |
In the latest World Health Organization (WHO) recommendation for Dengvaxia implementation, either serological testing or a person's history of prior dengue illness may be used as supporting evidence to identify dengue virus (DENV)-immune individuals eligible for vaccination, in areas with limited capacity for laboratory confirmation. This analysis aimed to estimate the concordance between self-reported dengue illness histories and seropositivity in a prospective cohort study for dengue virus infection in Kamphaeng Phet province, a dengue-endemic area in northern Thailand. The study enrolled 2,076 subjects from 516 multigenerational families, with a median age of 30.6 years (range 0-90 years). Individual and family member dengue illness histories were obtained by questionnaire. Seropositivity was defined based on hemagglutination inhibition (HAI) assays. Overall seropositivity for DENV was 86.5% among those aged 9-45 years, which increased with age. 18.5% of participants reported a history of dengue illness prior to enrollment; 30.1% reported a previous DENV infection in the family, and 40.1% reported DENV infection in either themselves or a family member. Relative to seropositivity by HAI in the vaccine candidate group, the sensitivity and specificity of individual prior dengue illness history were 18.5% and 81.6%, respectively; sensitivity and specificity of reported dengue illness in a family member were 29.8% and 68.0%, and of either the individual or a family member were 40.1% and 60.5%. Notably, 13.4% of individuals reporting prior dengue illness were seronegative. Given the high occurrence of asymptomatic and mild DENV infection, self-reported dengue illness history is poorly sensitive for prior exposure and may misclassify individuals as 'exposed' when they were not. This analysis highlights that a simple, highly sensitive, and highly specific test for determining serostatus prior to Dengvaxia vaccination is urgently needed. |
| format |
article |
| author |
Darunee Buddhari Kathryn B Anderson Gregory D Gromowski Richard G Jarman Sopon Iamsirithaworn Butsaya Thaisomboonsuk Taweewun Hunsawong Anon Srikiatkhachorn Alan L Rothman Anthony R Jones Stefan Fernandez Stephen J Thomas Timothy P Endy |
| author_facet |
Darunee Buddhari Kathryn B Anderson Gregory D Gromowski Richard G Jarman Sopon Iamsirithaworn Butsaya Thaisomboonsuk Taweewun Hunsawong Anon Srikiatkhachorn Alan L Rothman Anthony R Jones Stefan Fernandez Stephen J Thomas Timothy P Endy |
| author_sort |
Darunee Buddhari |
| title |
Correlation between reported dengue illness history and seropositivity in rural Thailand. |
| title_short |
Correlation between reported dengue illness history and seropositivity in rural Thailand. |
| title_full |
Correlation between reported dengue illness history and seropositivity in rural Thailand. |
| title_fullStr |
Correlation between reported dengue illness history and seropositivity in rural Thailand. |
| title_full_unstemmed |
Correlation between reported dengue illness history and seropositivity in rural Thailand. |
| title_sort |
correlation between reported dengue illness history and seropositivity in rural thailand. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/4a2efcfedd9c4ca78dccf8993dc38a16 |
| work_keys_str_mv |
AT daruneebuddhari correlationbetweenreporteddengueillnesshistoryandseropositivityinruralthailand AT kathrynbanderson correlationbetweenreporteddengueillnesshistoryandseropositivityinruralthailand AT gregorydgromowski correlationbetweenreporteddengueillnesshistoryandseropositivityinruralthailand AT richardgjarman correlationbetweenreporteddengueillnesshistoryandseropositivityinruralthailand AT soponiamsirithaworn correlationbetweenreporteddengueillnesshistoryandseropositivityinruralthailand AT butsayathaisomboonsuk correlationbetweenreporteddengueillnesshistoryandseropositivityinruralthailand AT taweewunhunsawong correlationbetweenreporteddengueillnesshistoryandseropositivityinruralthailand AT anonsrikiatkhachorn correlationbetweenreporteddengueillnesshistoryandseropositivityinruralthailand AT alanlrothman correlationbetweenreporteddengueillnesshistoryandseropositivityinruralthailand AT anthonyrjones correlationbetweenreporteddengueillnesshistoryandseropositivityinruralthailand AT stefanfernandez correlationbetweenreporteddengueillnesshistoryandseropositivityinruralthailand AT stephenjthomas correlationbetweenreporteddengueillnesshistoryandseropositivityinruralthailand AT timothypendy correlationbetweenreporteddengueillnesshistoryandseropositivityinruralthailand |
| _version_ |
1718413678698561536 |