Postsynaptic autism spectrum disorder genes and synaptic dysfunction

This review provides an overview of the synaptic dysfunction of neuronal circuits and the ensuing behavioral alterations caused by mutations in autism spectrum disorder (ASD)-linked genes directly or indirectly affecting the postsynaptic neuronal compartment. There are plenty of ASD risk genes, that...

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Autores principales:	Paola Bonsi, Antonella De Jaco, Laurent Fasano, Paolo Gubellini
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	ASD gene expression regulation Mitochondrial dysfunction Animal models of ASD Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/4a38312f798847fda51cd926156bb5e1
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spelling	oai:doaj.org-article:4a38312f798847fda51cd926156bb5e12021-11-28T04:28:37ZPostsynaptic autism spectrum disorder genes and synaptic dysfunction1095-953X10.1016/j.nbd.2021.105564https://doaj.org/article/4a38312f798847fda51cd926156bb5e12022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0969996121003132https://doaj.org/toc/1095-953XThis review provides an overview of the synaptic dysfunction of neuronal circuits and the ensuing behavioral alterations caused by mutations in autism spectrum disorder (ASD)-linked genes directly or indirectly affecting the postsynaptic neuronal compartment. There are plenty of ASD risk genes, that may be broadly grouped into those involved in gene expression regulation (epigenetic regulation and transcription) and genes regulating synaptic activity (neural communication and neurotransmission). Notably, the effects mediated by ASD-associated genes can vary extensively depending on the developmental time and/or subcellular site of expression. Therefore, in order to gain a better understanding of the mechanisms of disruptions in postsynaptic function, an effort to better model ASD in experimental animals is required to improve standardization and increase reproducibility within and among studies. Such an effort holds promise to provide deeper insight into the development of these disorders and to improve the translational value of preclinical studies.Paola BonsiAntonella De JacoLaurent FasanoPaolo GubelliniElsevierarticleASD gene expression regulationMitochondrial dysfunctionAnimal models of ASDNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeurobiology of Disease, Vol 162, Iss , Pp 105564- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	ASD gene expression regulation Mitochondrial dysfunction Animal models of ASD Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	ASD gene expression regulation Mitochondrial dysfunction Animal models of ASD Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Paola Bonsi Antonella De Jaco Laurent Fasano Paolo Gubellini Postsynaptic autism spectrum disorder genes and synaptic dysfunction
description	This review provides an overview of the synaptic dysfunction of neuronal circuits and the ensuing behavioral alterations caused by mutations in autism spectrum disorder (ASD)-linked genes directly or indirectly affecting the postsynaptic neuronal compartment. There are plenty of ASD risk genes, that may be broadly grouped into those involved in gene expression regulation (epigenetic regulation and transcription) and genes regulating synaptic activity (neural communication and neurotransmission). Notably, the effects mediated by ASD-associated genes can vary extensively depending on the developmental time and/or subcellular site of expression. Therefore, in order to gain a better understanding of the mechanisms of disruptions in postsynaptic function, an effort to better model ASD in experimental animals is required to improve standardization and increase reproducibility within and among studies. Such an effort holds promise to provide deeper insight into the development of these disorders and to improve the translational value of preclinical studies.
format	article
author	Paola Bonsi Antonella De Jaco Laurent Fasano Paolo Gubellini
author_facet	Paola Bonsi Antonella De Jaco Laurent Fasano Paolo Gubellini
author_sort	Paola Bonsi
title	Postsynaptic autism spectrum disorder genes and synaptic dysfunction
title_short	Postsynaptic autism spectrum disorder genes and synaptic dysfunction
title_full	Postsynaptic autism spectrum disorder genes and synaptic dysfunction
title_fullStr	Postsynaptic autism spectrum disorder genes and synaptic dysfunction
title_full_unstemmed	Postsynaptic autism spectrum disorder genes and synaptic dysfunction
title_sort	postsynaptic autism spectrum disorder genes and synaptic dysfunction
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/4a38312f798847fda51cd926156bb5e1
work_keys_str_mv	AT paolabonsi postsynapticautismspectrumdisordergenesandsynapticdysfunction AT antonelladejaco postsynapticautismspectrumdisordergenesandsynapticdysfunction AT laurentfasano postsynapticautismspectrumdisordergenesandsynapticdysfunction AT paologubellini postsynapticautismspectrumdisordergenesandsynapticdysfunction
_version_	1718408376024563712

Postsynaptic autism spectrum disorder genes and synaptic dysfunction

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