Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines

Ebola virus glycoprotein (GP) is a major target for vaccine design. Here, the authors identify mutations to improve GP stability and yield, design two multilayered nanoparticle carriers, and demonstrate good immunogenicity of the modified GP on nanoparticles in mice and rabbits.

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Autores principales:	Linling He, Anshul Chaudhary, Xiaohe Lin, Cindy Sou, Tanwee Alkutkar, Sonu Kumar, Timothy Ngo, Ezra Kosviner, Gabriel Ozorowski, Robyn L. Stanfield, Andrew B. Ward, Ian A. Wilson, Jiang Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4a392730803043be9929af5ed1751e87
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spelling	oai:doaj.org-article:4a392730803043be9929af5ed1751e872021-12-02T15:36:28ZSingle-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines10.1038/s41467-021-22867-w2041-1723https://doaj.org/article/4a392730803043be9929af5ed1751e872021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22867-whttps://doaj.org/toc/2041-1723Ebola virus glycoprotein (GP) is a major target for vaccine design. Here, the authors identify mutations to improve GP stability and yield, design two multilayered nanoparticle carriers, and demonstrate good immunogenicity of the modified GP on nanoparticles in mice and rabbits.Linling HeAnshul ChaudharyXiaohe LinCindy SouTanwee AlkutkarSonu KumarTimothy NgoEzra KosvinerGabriel OzorowskiRobyn L. StanfieldAndrew B. WardIan A. WilsonJiang ZhuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Linling He Anshul Chaudhary Xiaohe Lin Cindy Sou Tanwee Alkutkar Sonu Kumar Timothy Ngo Ezra Kosviner Gabriel Ozorowski Robyn L. Stanfield Andrew B. Ward Ian A. Wilson Jiang Zhu Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines
description	Ebola virus glycoprotein (GP) is a major target for vaccine design. Here, the authors identify mutations to improve GP stability and yield, design two multilayered nanoparticle carriers, and demonstrate good immunogenicity of the modified GP on nanoparticles in mice and rabbits.
format	article
author	Linling He Anshul Chaudhary Xiaohe Lin Cindy Sou Tanwee Alkutkar Sonu Kumar Timothy Ngo Ezra Kosviner Gabriel Ozorowski Robyn L. Stanfield Andrew B. Ward Ian A. Wilson Jiang Zhu
author_facet	Linling He Anshul Chaudhary Xiaohe Lin Cindy Sou Tanwee Alkutkar Sonu Kumar Timothy Ngo Ezra Kosviner Gabriel Ozorowski Robyn L. Stanfield Andrew B. Ward Ian A. Wilson Jiang Zhu
author_sort	Linling He
title	Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines
title_short	Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines
title_full	Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines
title_fullStr	Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines
title_full_unstemmed	Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines
title_sort	single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as ebola virus vaccines
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4a392730803043be9929af5ed1751e87
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Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines

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