Tilted grating phase-contrast computed tomography using statistical iterative reconstruction

Abstract Grating-based phase-contrast computed tomography (GBPC-CT) enables increased soft tissue differentiation, but often suffers from streak artifacts when performing high-sensitivity GBPC-CT of biomedical samples. Current GBPC-CT setups consist of one-dimensional gratings and hence allow to mea...

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Autores principales:	Lorenz Birnbacher, Manuel Viermetz, Wolfgang Noichl, Sebastian Allner, Andreas Fehringer, Mathias Marschner, Maximilian von Teuffenbach, Marian Willner, Klaus Achterhold, Peter B. Noël, Thomas Koehler, Julia Herzen, Franz Pfeiffer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4a399d65c7154894a6ff78a861e747e7
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spelling	oai:doaj.org-article:4a399d65c7154894a6ff78a861e747e72021-12-02T15:08:24ZTilted grating phase-contrast computed tomography using statistical iterative reconstruction10.1038/s41598-018-25075-72045-2322https://doaj.org/article/4a399d65c7154894a6ff78a861e747e72018-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25075-7https://doaj.org/toc/2045-2322Abstract Grating-based phase-contrast computed tomography (GBPC-CT) enables increased soft tissue differentiation, but often suffers from streak artifacts when performing high-sensitivity GBPC-CT of biomedical samples. Current GBPC-CT setups consist of one-dimensional gratings and hence allow to measure only the differential phase-contrast (DPC) signal perpendicular to the direction of the grating lines. Having access to the full two-dimensional DPC signal can strongly reduce streak artefacts showing up as characteristic horizontal lines in the reconstructed images. GBPC-CT with gratings tilted by 45° around the optical axis, combining opposed projections, and reconstructing with filtered backprojection is one method to retrieve the full three-dimensional DPC signal. This approach improves the quality of the tomographic data as already demonstrated at a synchrotron facility. However, additional processing and interpolation is necessary, and the approach fails when dealing with cone-beam geometry setups. In this work, we employ the tilted grating configuration with a laboratory GBPC-CT setup with cone-beam geometry and use statistical iterative reconstruction (SIR) with a forward model accounting for diagonal grating alignment. Our results show a strong reduction of streak artefacts and significant increase in image quality. In contrast to the prior approach our proposed method can be used in a laboratory environment due to its cone-beam compatibility.Lorenz BirnbacherManuel ViermetzWolfgang NoichlSebastian AllnerAndreas FehringerMathias MarschnerMaximilian von TeuffenbachMarian WillnerKlaus AchterholdPeter B. NoëlThomas KoehlerJulia HerzenFranz PfeifferNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lorenz Birnbacher Manuel Viermetz Wolfgang Noichl Sebastian Allner Andreas Fehringer Mathias Marschner Maximilian von Teuffenbach Marian Willner Klaus Achterhold Peter B. Noël Thomas Koehler Julia Herzen Franz Pfeiffer Tilted grating phase-contrast computed tomography using statistical iterative reconstruction
description	Abstract Grating-based phase-contrast computed tomography (GBPC-CT) enables increased soft tissue differentiation, but often suffers from streak artifacts when performing high-sensitivity GBPC-CT of biomedical samples. Current GBPC-CT setups consist of one-dimensional gratings and hence allow to measure only the differential phase-contrast (DPC) signal perpendicular to the direction of the grating lines. Having access to the full two-dimensional DPC signal can strongly reduce streak artefacts showing up as characteristic horizontal lines in the reconstructed images. GBPC-CT with gratings tilted by 45° around the optical axis, combining opposed projections, and reconstructing with filtered backprojection is one method to retrieve the full three-dimensional DPC signal. This approach improves the quality of the tomographic data as already demonstrated at a synchrotron facility. However, additional processing and interpolation is necessary, and the approach fails when dealing with cone-beam geometry setups. In this work, we employ the tilted grating configuration with a laboratory GBPC-CT setup with cone-beam geometry and use statistical iterative reconstruction (SIR) with a forward model accounting for diagonal grating alignment. Our results show a strong reduction of streak artefacts and significant increase in image quality. In contrast to the prior approach our proposed method can be used in a laboratory environment due to its cone-beam compatibility.
format	article
author	Lorenz Birnbacher Manuel Viermetz Wolfgang Noichl Sebastian Allner Andreas Fehringer Mathias Marschner Maximilian von Teuffenbach Marian Willner Klaus Achterhold Peter B. Noël Thomas Koehler Julia Herzen Franz Pfeiffer
author_facet	Lorenz Birnbacher Manuel Viermetz Wolfgang Noichl Sebastian Allner Andreas Fehringer Mathias Marschner Maximilian von Teuffenbach Marian Willner Klaus Achterhold Peter B. Noël Thomas Koehler Julia Herzen Franz Pfeiffer
author_sort	Lorenz Birnbacher
title	Tilted grating phase-contrast computed tomography using statistical iterative reconstruction
title_short	Tilted grating phase-contrast computed tomography using statistical iterative reconstruction
title_full	Tilted grating phase-contrast computed tomography using statistical iterative reconstruction
title_fullStr	Tilted grating phase-contrast computed tomography using statistical iterative reconstruction
title_full_unstemmed	Tilted grating phase-contrast computed tomography using statistical iterative reconstruction
title_sort	tilted grating phase-contrast computed tomography using statistical iterative reconstruction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4a399d65c7154894a6ff78a861e747e7
work_keys_str_mv	AT lorenzbirnbacher tiltedgratingphasecontrastcomputedtomographyusingstatisticaliterativereconstruction AT manuelviermetz tiltedgratingphasecontrastcomputedtomographyusingstatisticaliterativereconstruction AT wolfgangnoichl tiltedgratingphasecontrastcomputedtomographyusingstatisticaliterativereconstruction AT sebastianallner tiltedgratingphasecontrastcomputedtomographyusingstatisticaliterativereconstruction AT andreasfehringer tiltedgratingphasecontrastcomputedtomographyusingstatisticaliterativereconstruction AT mathiasmarschner tiltedgratingphasecontrastcomputedtomographyusingstatisticaliterativereconstruction AT maximilianvonteuffenbach tiltedgratingphasecontrastcomputedtomographyusingstatisticaliterativereconstruction AT marianwillner tiltedgratingphasecontrastcomputedtomographyusingstatisticaliterativereconstruction AT klausachterhold tiltedgratingphasecontrastcomputedtomographyusingstatisticaliterativereconstruction AT peterbnoel tiltedgratingphasecontrastcomputedtomographyusingstatisticaliterativereconstruction AT thomaskoehler tiltedgratingphasecontrastcomputedtomographyusingstatisticaliterativereconstruction AT juliaherzen tiltedgratingphasecontrastcomputedtomographyusingstatisticaliterativereconstruction AT franzpfeiffer tiltedgratingphasecontrastcomputedtomographyusingstatisticaliterativereconstruction
_version_	1718388118787194880

Tilted grating phase-contrast computed tomography using statistical iterative reconstruction

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