The Role of Environmental PM2.5 in Admission Acute Heart Failure in ST-Elevation Myocardial Infarction patients - An Observational Retrospective Study

Andreja Sinkovic,1 Andrej Markota,1 Manja Krasevec,2 David Suran,3 Martin Marinsek1 1Department of Medical Intensive Care, University Clinical Centre Maribor, Maribor, Slovenia; 2Medical Faculty of University Maribor, Maribor, Slovenia; 3Department of Cardiology, University Clinical Centre Maribor,...

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Autores principales:	Sinkovic A, Markota A, Krasevec M, Suran D, Marinsek M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	admission acute heart failure st-elevation myocardial infarction air pollution pm2.5 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4a3f2e241fe74921a9fce91aa75459db
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spelling	oai:doaj.org-article:4a3f2e241fe74921a9fce91aa75459db2021-11-18T19:40:25ZThe Role of Environmental PM2.5 in Admission Acute Heart Failure in ST-Elevation Myocardial Infarction patients - An Observational Retrospective Study1178-7074https://doaj.org/article/4a3f2e241fe74921a9fce91aa75459db2021-11-01T00:00:00Zhttps://www.dovepress.com/the-role-of-environmental-pm25-in-admission-acute-heart-failure-in-st--peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Andreja Sinkovic,1 Andrej Markota,1 Manja Krasevec,2 David Suran,3 Martin Marinsek1 1Department of Medical Intensive Care, University Clinical Centre Maribor, Maribor, Slovenia; 2Medical Faculty of University Maribor, Maribor, Slovenia; 3Department of Cardiology, University Clinical Centre Maribor, Maribor, SloveniaCorrespondence: Andreja SinkovicDepartment of Medical Intensive Care, University Clinical Centre Maribor, Ljubljanska 5, Maribor, 2000, SloveniaTel +38641337822Email andreja.sinkovic@guest.arnes.siBackground: Air pollution with increased concentrations of fine (< 2.5 μm) particulate matter (PM2.5) increases the risk of cardiovascular morbidity and mortality. Even short-term increase of PM2.5 may help trigger ST-elevation myocardial infarction (STEMI) and heart failure (HF) in susceptible individuals, even in areas with good air quality.Purpose: To evaluate the role of PM2.5 levels ≥ 20 μg/m3 in admission acute HF in STEMI patients.Materials and Methods: In 290 STEMI patients with the leading reperfusion strategy primary percutaneous coronary intervention (PPCI), we retrospectively studied independent predictors of admission acute HF and included admission demographic and clinical data as well as ambient PM2.5 levels ≥ 20 μg/m3. We defined admission acute HF in STEMI patients as classes II–IV by Killip Kimball classification.Results: Acute admission HF was observed in 34.5% of STEMI patients. PPCI was performed in 87.1% of acute admission HF patients and in 94.7% non-HF patients (p= 0.037). Significant independent predictors of acute admission HF were prior diabetes (OR 2.440, 95% CI 1.100 to 5.400, p=0.028), admission LBBB (OR 10.190, 95% CI 1.160 to 89.360, p=0.036), prior resuscitation (OR 2.530, 95% CI 1.010 to 6.340, p=0.048), admission troponin I≥ 5μg/l (OR 3.390, 95% CI 1.740 to 6.620, p< 0.001), admission eGFR levels (0.61, 95% CI 0.52 to 0.72, p < 0.001), and levels of PM2.5 ≥ 20 μg/m3 (OR 2.140, 95% CI 1.005 to 4.560, p=0.049) one day before admission.Conclusion: Temporary short-term increase in PM2.5 levels (≥ 20 μg/m3) one day prior to admission in an area with mainly good air quality was among significant independent predictors of acute admission HF in STEMI patients.Keywords: admission acute heart failure, ST-elevation myocardial infarction, air pollution, PM2.5Sinkovic AMarkota AKrasevec MSuran DMarinsek MDove Medical Pressarticleadmission acute heart failurest-elevation myocardial infarctionair pollutionpm2.5Medicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 8473-8479 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	admission acute heart failure st-elevation myocardial infarction air pollution pm2.5 Medicine (General) R5-920
spellingShingle	admission acute heart failure st-elevation myocardial infarction air pollution pm2.5 Medicine (General) R5-920 Sinkovic A Markota A Krasevec M Suran D Marinsek M The Role of Environmental PM2.5 in Admission Acute Heart Failure in ST-Elevation Myocardial Infarction patients - An Observational Retrospective Study
description	Andreja Sinkovic,1 Andrej Markota,1 Manja Krasevec,2 David Suran,3 Martin Marinsek1 1Department of Medical Intensive Care, University Clinical Centre Maribor, Maribor, Slovenia; 2Medical Faculty of University Maribor, Maribor, Slovenia; 3Department of Cardiology, University Clinical Centre Maribor, Maribor, SloveniaCorrespondence: Andreja SinkovicDepartment of Medical Intensive Care, University Clinical Centre Maribor, Ljubljanska 5, Maribor, 2000, SloveniaTel +38641337822Email andreja.sinkovic@guest.arnes.siBackground: Air pollution with increased concentrations of fine (< 2.5 μm) particulate matter (PM2.5) increases the risk of cardiovascular morbidity and mortality. Even short-term increase of PM2.5 may help trigger ST-elevation myocardial infarction (STEMI) and heart failure (HF) in susceptible individuals, even in areas with good air quality.Purpose: To evaluate the role of PM2.5 levels ≥ 20 μg/m3 in admission acute HF in STEMI patients.Materials and Methods: In 290 STEMI patients with the leading reperfusion strategy primary percutaneous coronary intervention (PPCI), we retrospectively studied independent predictors of admission acute HF and included admission demographic and clinical data as well as ambient PM2.5 levels ≥ 20 μg/m3. We defined admission acute HF in STEMI patients as classes II–IV by Killip Kimball classification.Results: Acute admission HF was observed in 34.5% of STEMI patients. PPCI was performed in 87.1% of acute admission HF patients and in 94.7% non-HF patients (p= 0.037). Significant independent predictors of acute admission HF were prior diabetes (OR 2.440, 95% CI 1.100 to 5.400, p=0.028), admission LBBB (OR 10.190, 95% CI 1.160 to 89.360, p=0.036), prior resuscitation (OR 2.530, 95% CI 1.010 to 6.340, p=0.048), admission troponin I≥ 5μg/l (OR 3.390, 95% CI 1.740 to 6.620, p< 0.001), admission eGFR levels (0.61, 95% CI 0.52 to 0.72, p < 0.001), and levels of PM2.5 ≥ 20 μg/m3 (OR 2.140, 95% CI 1.005 to 4.560, p=0.049) one day before admission.Conclusion: Temporary short-term increase in PM2.5 levels (≥ 20 μg/m3) one day prior to admission in an area with mainly good air quality was among significant independent predictors of acute admission HF in STEMI patients.Keywords: admission acute heart failure, ST-elevation myocardial infarction, air pollution, PM2.5
format	article
author	Sinkovic A Markota A Krasevec M Suran D Marinsek M
author_facet	Sinkovic A Markota A Krasevec M Suran D Marinsek M
author_sort	Sinkovic A
title	The Role of Environmental PM2.5 in Admission Acute Heart Failure in ST-Elevation Myocardial Infarction patients - An Observational Retrospective Study
title_short	The Role of Environmental PM2.5 in Admission Acute Heart Failure in ST-Elevation Myocardial Infarction patients - An Observational Retrospective Study
title_full	The Role of Environmental PM2.5 in Admission Acute Heart Failure in ST-Elevation Myocardial Infarction patients - An Observational Retrospective Study
title_fullStr	The Role of Environmental PM2.5 in Admission Acute Heart Failure in ST-Elevation Myocardial Infarction patients - An Observational Retrospective Study
title_full_unstemmed	The Role of Environmental PM2.5 in Admission Acute Heart Failure in ST-Elevation Myocardial Infarction patients - An Observational Retrospective Study
title_sort	role of environmental pm2.5 in admission acute heart failure in st-elevation myocardial infarction patients - an observational retrospective study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/4a3f2e241fe74921a9fce91aa75459db
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The Role of Environmental PM2.5 in Admission Acute Heart Failure in ST-Elevation Myocardial Infarction patients - An Observational Retrospective Study

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