Subventricular zone involvement is associated with worse outcome in glioma WHO grade 2 depending on molecular markers

Abstract Neural stem cells within the subventricular zone were identified as cells of origin driving growth of high-grade gliomas, and anatomical involvement of the subventricular zone has been associated with an inferior clinical outcome. Whether the association between poor outcome and subventricu...

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Autores principales:	Philipp Karschnia, Jonathan Weller, Jens Blobner, Veit M. Stoecklein, Mario M. Dorostkar, Kai Rejeski, Robert Forbrig, Maximilian Niyazi, Louisa von Baumgarten, Jorg Dietrich, Joerg-Christian Tonn, Niklas Thon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4a3f8ed6334e4c18b870dfcb35a3b312
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spelling	oai:doaj.org-article:4a3f8ed6334e4c18b870dfcb35a3b3122021-12-02T18:01:40ZSubventricular zone involvement is associated with worse outcome in glioma WHO grade 2 depending on molecular markers10.1038/s41598-021-97714-52045-2322https://doaj.org/article/4a3f8ed6334e4c18b870dfcb35a3b3122021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97714-5https://doaj.org/toc/2045-2322Abstract Neural stem cells within the subventricular zone were identified as cells of origin driving growth of high-grade gliomas, and anatomical involvement of the subventricular zone has been associated with an inferior clinical outcome. Whether the association between poor outcome and subventricular zone involvement also applies to glioma of lower grades is unclear. We therefore analysed a retrospective cohort of 182 patients with glioma grade 2 (according to the WHO 2016 classification) including 78 individuals (43%) with subventricular zone involvement. Patients with and without subventricular zone involvement did not differ in regard to demographics, histopathology, and molecular markers. Notably, subventricular zone involvement was a negative prognostic marker for malignant progression and overall survival on uni- and multivariate analysis. When patients were stratified according to the cIMPACT-NOW update 6, subventricular zone involvement was negatively associated with outcome in IDH-wildtype astrocytomas and 1p19q-codeleted oligodendrogliomas but not in IDH-mutant astrocytomas. Collectively, subventricular zone involvement may represent a risk factor for worse outcome in glioma WHO grade 2 depending on the molecular tumor signature. The present data confirm the relevance of molecular glioma classifications as proposed by the cIMPACT-NOW update 6. These findings warrant evaluation in prospective cohorts.Philipp KarschniaJonathan WellerJens BlobnerVeit M. StoeckleinMario M. DorostkarKai RejeskiRobert ForbrigMaximilian NiyaziLouisa von BaumgartenJorg DietrichJoerg-Christian TonnNiklas ThonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Philipp Karschnia Jonathan Weller Jens Blobner Veit M. Stoecklein Mario M. Dorostkar Kai Rejeski Robert Forbrig Maximilian Niyazi Louisa von Baumgarten Jorg Dietrich Joerg-Christian Tonn Niklas Thon Subventricular zone involvement is associated with worse outcome in glioma WHO grade 2 depending on molecular markers
description	Abstract Neural stem cells within the subventricular zone were identified as cells of origin driving growth of high-grade gliomas, and anatomical involvement of the subventricular zone has been associated with an inferior clinical outcome. Whether the association between poor outcome and subventricular zone involvement also applies to glioma of lower grades is unclear. We therefore analysed a retrospective cohort of 182 patients with glioma grade 2 (according to the WHO 2016 classification) including 78 individuals (43%) with subventricular zone involvement. Patients with and without subventricular zone involvement did not differ in regard to demographics, histopathology, and molecular markers. Notably, subventricular zone involvement was a negative prognostic marker for malignant progression and overall survival on uni- and multivariate analysis. When patients were stratified according to the cIMPACT-NOW update 6, subventricular zone involvement was negatively associated with outcome in IDH-wildtype astrocytomas and 1p19q-codeleted oligodendrogliomas but not in IDH-mutant astrocytomas. Collectively, subventricular zone involvement may represent a risk factor for worse outcome in glioma WHO grade 2 depending on the molecular tumor signature. The present data confirm the relevance of molecular glioma classifications as proposed by the cIMPACT-NOW update 6. These findings warrant evaluation in prospective cohorts.
format	article
author	Philipp Karschnia Jonathan Weller Jens Blobner Veit M. Stoecklein Mario M. Dorostkar Kai Rejeski Robert Forbrig Maximilian Niyazi Louisa von Baumgarten Jorg Dietrich Joerg-Christian Tonn Niklas Thon
author_facet	Philipp Karschnia Jonathan Weller Jens Blobner Veit M. Stoecklein Mario M. Dorostkar Kai Rejeski Robert Forbrig Maximilian Niyazi Louisa von Baumgarten Jorg Dietrich Joerg-Christian Tonn Niklas Thon
author_sort	Philipp Karschnia
title	Subventricular zone involvement is associated with worse outcome in glioma WHO grade 2 depending on molecular markers
title_short	Subventricular zone involvement is associated with worse outcome in glioma WHO grade 2 depending on molecular markers
title_full	Subventricular zone involvement is associated with worse outcome in glioma WHO grade 2 depending on molecular markers
title_fullStr	Subventricular zone involvement is associated with worse outcome in glioma WHO grade 2 depending on molecular markers
title_full_unstemmed	Subventricular zone involvement is associated with worse outcome in glioma WHO grade 2 depending on molecular markers
title_sort	subventricular zone involvement is associated with worse outcome in glioma who grade 2 depending on molecular markers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4a3f8ed6334e4c18b870dfcb35a3b312
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Subventricular zone involvement is associated with worse outcome in glioma WHO grade 2 depending on molecular markers

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