Continuous reference intervals for pediatric testosterone, sex hormone binding globulin and free testosterone using quantile regression

Testosterone (T), sex hormone binding globulin (SHBG), free testosterone (FT) and bioavailable testosterone (BAT) are commonly employed tests in pediatric endocrinology and all require age-dependent reference intervals for interpretation. The common methods used to derive these reference intervals r...

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Autores principales:	Daniel T. Holmes, J Grace van der Gugten, Benjamin Jung, Christopher R. McCudden
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/4a4013125a504867aa0893e0a1963073
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spelling	oai:doaj.org-article:4a4013125a504867aa0893e0a19630732021-11-20T05:16:07ZContinuous reference intervals for pediatric testosterone, sex hormone binding globulin and free testosterone using quantile regression2667-145X10.1016/j.jmsacl.2021.10.005https://doaj.org/article/4a4013125a504867aa0893e0a19630732021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667145X21000250https://doaj.org/toc/2667-145XTestosterone (T), sex hormone binding globulin (SHBG), free testosterone (FT) and bioavailable testosterone (BAT) are commonly employed tests in pediatric endocrinology and all require age-dependent reference intervals for interpretation. The common methods used to derive these reference intervals require decisions about data shape and/or age partition thresholds, which can result in sharp differences between age groups, particularly for pubescent children. Partitioning also results in a form of data loss, where data from one age-bin is completed disconnected from the adjacent age-bins. Non-parametric continuous reference intervals methods have previously been developed to avoid some of these drawbacks. These strategies use all the available data and smooth transitions between ages avoiding partitioning. However, the fitting process involves selection and adjustment of many parameters and it can be difficult to maintain a reproducible approach. Here we provide a workflow for non-parametric continuous reference intervals applied to T, FT, BAT, and SHBG using the R language quantregGrowth package. T measurements were determined by LC-MS/MS, FT and BAT were calculated, and SHBG was measured on the Roche Cobas e601. The continuous interval methodology is described in detail with code examples and illustrations for reproducibility.Daniel T. HolmesJ Grace van der GugtenBenjamin JungChristopher R. McCuddenElsevierarticleMedical technologyR855-855.5ENJournal of Mass Spectrometry and Advances in the Clinical Lab, Vol 22, Iss , Pp 64-70 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5
spellingShingle	Medical technology R855-855.5 Daniel T. Holmes J Grace van der Gugten Benjamin Jung Christopher R. McCudden Continuous reference intervals for pediatric testosterone, sex hormone binding globulin and free testosterone using quantile regression
description	Testosterone (T), sex hormone binding globulin (SHBG), free testosterone (FT) and bioavailable testosterone (BAT) are commonly employed tests in pediatric endocrinology and all require age-dependent reference intervals for interpretation. The common methods used to derive these reference intervals require decisions about data shape and/or age partition thresholds, which can result in sharp differences between age groups, particularly for pubescent children. Partitioning also results in a form of data loss, where data from one age-bin is completed disconnected from the adjacent age-bins. Non-parametric continuous reference intervals methods have previously been developed to avoid some of these drawbacks. These strategies use all the available data and smooth transitions between ages avoiding partitioning. However, the fitting process involves selection and adjustment of many parameters and it can be difficult to maintain a reproducible approach. Here we provide a workflow for non-parametric continuous reference intervals applied to T, FT, BAT, and SHBG using the R language quantregGrowth package. T measurements were determined by LC-MS/MS, FT and BAT were calculated, and SHBG was measured on the Roche Cobas e601. The continuous interval methodology is described in detail with code examples and illustrations for reproducibility.
format	article
author	Daniel T. Holmes J Grace van der Gugten Benjamin Jung Christopher R. McCudden
author_facet	Daniel T. Holmes J Grace van der Gugten Benjamin Jung Christopher R. McCudden
author_sort	Daniel T. Holmes
title	Continuous reference intervals for pediatric testosterone, sex hormone binding globulin and free testosterone using quantile regression
title_short	Continuous reference intervals for pediatric testosterone, sex hormone binding globulin and free testosterone using quantile regression
title_full	Continuous reference intervals for pediatric testosterone, sex hormone binding globulin and free testosterone using quantile regression
title_fullStr	Continuous reference intervals for pediatric testosterone, sex hormone binding globulin and free testosterone using quantile regression
title_full_unstemmed	Continuous reference intervals for pediatric testosterone, sex hormone binding globulin and free testosterone using quantile regression
title_sort	continuous reference intervals for pediatric testosterone, sex hormone binding globulin and free testosterone using quantile regression
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/4a4013125a504867aa0893e0a1963073
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Continuous reference intervals for pediatric testosterone, sex hormone binding globulin and free testosterone using quantile regression

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