Targeted therapy of intracranial glioma model mice with curcumin nanoliposomes

Ming Zhao,* Mengnan Zhao,* Chen Fu, Yang Yu, Ailing Fu School of Pharmaceutical Sciences, Southwest University, Chongqing, People’s Republic of China *These authors contributed equally to this work Background: Glioma is the most aggressive and lethal brain tumor in humans, it comprises...

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Autores principales:	Zhao M, Fu C, Yu Y, Fu A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	glioma targeted delivery cell apoptosis cell cycle survival time Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4a4043cccd3148acbd92a314df9b8195
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spelling	oai:doaj.org-article:4a4043cccd3148acbd92a314df9b81952021-12-02T02:50:59ZTargeted therapy of intracranial glioma model mice with curcumin nanoliposomes1178-2013https://doaj.org/article/4a4043cccd3148acbd92a314df9b81952018-03-01T00:00:00Zhttps://www.dovepress.com/targeted-therapy-of-intracranial-glioma-model-mice-with-curcumin-nanol-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ming Zhao,* Mengnan Zhao,* Chen Fu, Yang Yu, Ailing Fu School of Pharmaceutical Sciences, Southwest University, Chongqing, People’s Republic of China *These authors contributed equally to this work Background: Glioma is the most aggressive and lethal brain tumor in humans, it comprises about 30 per cent of all brain tumors and central nervous system tumors. Purpose: The objective of this study was to create novel brain-targeting nanoliposomes to encapsulate curcumin as a promising option for glioma therapy. Patients and methods: Human glioma cells (U251MG) were used to determine cell uptake efficiency and possible internalization mechanism of the curcumin-loaded nanoliposomes modified by a brain-targeting peptide RDP. In addition, intracranial glioma mice model was prepared by transplantation of U251MG cells into the mice striatum, and then the liposomes were intravenously administered into the glioma-bearing mice to evaluate the anti-glioma activity. Results: RDP-modified liposomes (RCL) could enter the brain and glioma region, and were internalized by the glioma cells perhaps through acetylcholine receptor-mediated endocytosis pathway. Furthermore, the RCL prolonged the survival time of the glioma-bearing mice from 23 to 33 days, and the inhibition mechanism of the RCL on glioma cell was partly due to cell cycle arrest at the S phase and induction of cell apoptosis.Conclusion: This study would provide a potential approach for targeted delivery of drug-loaded liposomes for glioma treatment. Keywords: glioma, targeted delivery, cell apoptosis, cell cycle, survival timeZhao MZhao MFu CYu YFu ADove Medical Pressarticlegliomatargeted deliverycell apoptosiscell cyclesurvival timeMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 1601-1610 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	glioma targeted delivery cell apoptosis cell cycle survival time Medicine (General) R5-920
spellingShingle	glioma targeted delivery cell apoptosis cell cycle survival time Medicine (General) R5-920 Zhao M Zhao M Fu C Yu Y Fu A Targeted therapy of intracranial glioma model mice with curcumin nanoliposomes
description	Ming Zhao,* Mengnan Zhao,* Chen Fu, Yang Yu, Ailing Fu School of Pharmaceutical Sciences, Southwest University, Chongqing, People’s Republic of China *These authors contributed equally to this work Background: Glioma is the most aggressive and lethal brain tumor in humans, it comprises about 30 per cent of all brain tumors and central nervous system tumors. Purpose: The objective of this study was to create novel brain-targeting nanoliposomes to encapsulate curcumin as a promising option for glioma therapy. Patients and methods: Human glioma cells (U251MG) were used to determine cell uptake efficiency and possible internalization mechanism of the curcumin-loaded nanoliposomes modified by a brain-targeting peptide RDP. In addition, intracranial glioma mice model was prepared by transplantation of U251MG cells into the mice striatum, and then the liposomes were intravenously administered into the glioma-bearing mice to evaluate the anti-glioma activity. Results: RDP-modified liposomes (RCL) could enter the brain and glioma region, and were internalized by the glioma cells perhaps through acetylcholine receptor-mediated endocytosis pathway. Furthermore, the RCL prolonged the survival time of the glioma-bearing mice from 23 to 33 days, and the inhibition mechanism of the RCL on glioma cell was partly due to cell cycle arrest at the S phase and induction of cell apoptosis.Conclusion: This study would provide a potential approach for targeted delivery of drug-loaded liposomes for glioma treatment. Keywords: glioma, targeted delivery, cell apoptosis, cell cycle, survival time
format	article
author	Zhao M Zhao M Fu C Yu Y Fu A
author_facet	Zhao M Zhao M Fu C Yu Y Fu A
author_sort	Zhao M
title	Targeted therapy of intracranial glioma model mice with curcumin nanoliposomes
title_short	Targeted therapy of intracranial glioma model mice with curcumin nanoliposomes
title_full	Targeted therapy of intracranial glioma model mice with curcumin nanoliposomes
title_fullStr	Targeted therapy of intracranial glioma model mice with curcumin nanoliposomes
title_full_unstemmed	Targeted therapy of intracranial glioma model mice with curcumin nanoliposomes
title_sort	targeted therapy of intracranial glioma model mice with curcumin nanoliposomes
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/4a4043cccd3148acbd92a314df9b8195
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Targeted therapy of intracranial glioma model mice with curcumin nanoliposomes

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