Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1

RNA-binding protein hnRNP A2/B1 is suggested to promote miRNA processing as a m6A 'reader'. Here, the authors determine crystal structures of RRM domains of hnRNP A2/B1 in complex with various RNA substrates and determine that hnRNP A2/B1 may function as an auxiliary factor in 'm6A sw...

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Autores principales:	Baixing Wu, Shichen Su, Deepak P. Patil, Hehua Liu, Jianhua Gan, Samie R. Jaffrey, Jinbiao Ma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4a42d300b72c449a91ee0c967c3ae42c
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spelling	oai:doaj.org-article:4a42d300b72c449a91ee0c967c3ae42c2021-12-02T15:34:14ZMolecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B110.1038/s41467-017-02770-z2041-1723https://doaj.org/article/4a42d300b72c449a91ee0c967c3ae42c2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02770-zhttps://doaj.org/toc/2041-1723RNA-binding protein hnRNP A2/B1 is suggested to promote miRNA processing as a m6A 'reader'. Here, the authors determine crystal structures of RRM domains of hnRNP A2/B1 in complex with various RNA substrates and determine that hnRNP A2/B1 may function as an auxiliary factor in 'm6A switch' instead.Baixing WuShichen SuDeepak P. PatilHehua LiuJianhua GanSamie R. JaffreyJinbiao MaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Baixing Wu Shichen Su Deepak P. Patil Hehua Liu Jianhua Gan Samie R. Jaffrey Jinbiao Ma Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1
description	RNA-binding protein hnRNP A2/B1 is suggested to promote miRNA processing as a m6A 'reader'. Here, the authors determine crystal structures of RRM domains of hnRNP A2/B1 in complex with various RNA substrates and determine that hnRNP A2/B1 may function as an auxiliary factor in 'm6A switch' instead.
format	article
author	Baixing Wu Shichen Su Deepak P. Patil Hehua Liu Jianhua Gan Samie R. Jaffrey Jinbiao Ma
author_facet	Baixing Wu Shichen Su Deepak P. Patil Hehua Liu Jianhua Gan Samie R. Jaffrey Jinbiao Ma
author_sort	Baixing Wu
title	Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1
title_short	Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1
title_full	Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1
title_fullStr	Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1
title_full_unstemmed	Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1
title_sort	molecular basis for the specific and multivariant recognitions of rna substrates by human hnrnp a2/b1
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4a42d300b72c449a91ee0c967c3ae42c
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Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1

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