Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1

Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1

RNA-binding protein hnRNP A2/B1 is suggested to promote miRNA processing as a m6A 'reader'. Here, the authors determine crystal structures of RRM domains of hnRNP A2/B1 in complex with various RNA substrates and determine that hnRNP A2/B1 may function as an auxiliary factor in 'm6A sw...

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Autores principales: Baixing Wu, Shichen Su, Deepak P. Patil, Hehua Liu, Jianhua Gan, Samie R. Jaffrey, Jinbiao Ma
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/4a42d300b72c449a91ee0c967c3ae42c
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