Programmed cell senescence in skeleton during late puberty

Mesenchymal stem cells are essential for bone development, but it is unclear if their activity is maintained after late puberty, when bone growth decelerates. The authors show that during late puberty in mice, these cells undergo senescence under the epigenetic control of Ezh2.

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Autores principales:	Changjun Li, Yu Chai, Lei Wang, Bo Gao, Hao Chen, Peisong Gao, Feng-Quan Zhou, Xianghang Luo, Janet L. Crane, Bin Yu, Xu Cao, Mei Wan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4a45054ad544440fb6c5efb9d5044ffb
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spelling	oai:doaj.org-article:4a45054ad544440fb6c5efb9d5044ffb2021-12-02T17:06:25ZProgrammed cell senescence in skeleton during late puberty10.1038/s41467-017-01509-02041-1723https://doaj.org/article/4a45054ad544440fb6c5efb9d5044ffb2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01509-0https://doaj.org/toc/2041-1723Mesenchymal stem cells are essential for bone development, but it is unclear if their activity is maintained after late puberty, when bone growth decelerates. The authors show that during late puberty in mice, these cells undergo senescence under the epigenetic control of Ezh2.Changjun LiYu ChaiLei WangBo GaoHao ChenPeisong GaoFeng-Quan ZhouXianghang LuoJanet L. CraneBin YuXu CaoMei WanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Changjun Li Yu Chai Lei Wang Bo Gao Hao Chen Peisong Gao Feng-Quan Zhou Xianghang Luo Janet L. Crane Bin Yu Xu Cao Mei Wan Programmed cell senescence in skeleton during late puberty
description	Mesenchymal stem cells are essential for bone development, but it is unclear if their activity is maintained after late puberty, when bone growth decelerates. The authors show that during late puberty in mice, these cells undergo senescence under the epigenetic control of Ezh2.
format	article
author	Changjun Li Yu Chai Lei Wang Bo Gao Hao Chen Peisong Gao Feng-Quan Zhou Xianghang Luo Janet L. Crane Bin Yu Xu Cao Mei Wan
author_facet	Changjun Li Yu Chai Lei Wang Bo Gao Hao Chen Peisong Gao Feng-Quan Zhou Xianghang Luo Janet L. Crane Bin Yu Xu Cao Mei Wan
author_sort	Changjun Li
title	Programmed cell senescence in skeleton during late puberty
title_short	Programmed cell senescence in skeleton during late puberty
title_full	Programmed cell senescence in skeleton during late puberty
title_fullStr	Programmed cell senescence in skeleton during late puberty
title_full_unstemmed	Programmed cell senescence in skeleton during late puberty
title_sort	programmed cell senescence in skeleton during late puberty
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4a45054ad544440fb6c5efb9d5044ffb
work_keys_str_mv	AT changjunli programmedcellsenescenceinskeletonduringlatepuberty AT yuchai programmedcellsenescenceinskeletonduringlatepuberty AT leiwang programmedcellsenescenceinskeletonduringlatepuberty AT bogao programmedcellsenescenceinskeletonduringlatepuberty AT haochen programmedcellsenescenceinskeletonduringlatepuberty AT peisonggao programmedcellsenescenceinskeletonduringlatepuberty AT fengquanzhou programmedcellsenescenceinskeletonduringlatepuberty AT xianghangluo programmedcellsenescenceinskeletonduringlatepuberty AT janetlcrane programmedcellsenescenceinskeletonduringlatepuberty AT binyu programmedcellsenescenceinskeletonduringlatepuberty AT xucao programmedcellsenescenceinskeletonduringlatepuberty AT meiwan programmedcellsenescenceinskeletonduringlatepuberty
_version_	1718381611110629376

Programmed cell senescence in skeleton during late puberty

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