Programmed cell senescence in skeleton during late puberty

Mesenchymal stem cells are essential for bone development, but it is unclear if their activity is maintained after late puberty, when bone growth decelerates. The authors show that during late puberty in mice, these cells undergo senescence under the epigenetic control of Ezh2.

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Bibliographic Details
Main Authors:	Changjun Li, Yu Chai, Lei Wang, Bo Gao, Hao Chen, Peisong Gao, Feng-Quan Zhou, Xianghang Luo, Janet L. Crane, Bin Yu, Xu Cao, Mei Wan
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/4a45054ad544440fb6c5efb9d5044ffb
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spelling	oai:doaj.org-article:4a45054ad544440fb6c5efb9d5044ffb2021-12-02T17:06:25ZProgrammed cell senescence in skeleton during late puberty10.1038/s41467-017-01509-02041-1723https://doaj.org/article/4a45054ad544440fb6c5efb9d5044ffb2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01509-0https://doaj.org/toc/2041-1723Mesenchymal stem cells are essential for bone development, but it is unclear if their activity is maintained after late puberty, when bone growth decelerates. The authors show that during late puberty in mice, these cells undergo senescence under the epigenetic control of Ezh2.Changjun LiYu ChaiLei WangBo GaoHao ChenPeisong GaoFeng-Quan ZhouXianghang LuoJanet L. CraneBin YuXu CaoMei WanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Changjun Li Yu Chai Lei Wang Bo Gao Hao Chen Peisong Gao Feng-Quan Zhou Xianghang Luo Janet L. Crane Bin Yu Xu Cao Mei Wan Programmed cell senescence in skeleton during late puberty
description	Mesenchymal stem cells are essential for bone development, but it is unclear if their activity is maintained after late puberty, when bone growth decelerates. The authors show that during late puberty in mice, these cells undergo senescence under the epigenetic control of Ezh2.
format	article
author	Changjun Li Yu Chai Lei Wang Bo Gao Hao Chen Peisong Gao Feng-Quan Zhou Xianghang Luo Janet L. Crane Bin Yu Xu Cao Mei Wan
author_facet	Changjun Li Yu Chai Lei Wang Bo Gao Hao Chen Peisong Gao Feng-Quan Zhou Xianghang Luo Janet L. Crane Bin Yu Xu Cao Mei Wan
author_sort	Changjun Li
title	Programmed cell senescence in skeleton during late puberty
title_short	Programmed cell senescence in skeleton during late puberty
title_full	Programmed cell senescence in skeleton during late puberty
title_fullStr	Programmed cell senescence in skeleton during late puberty
title_full_unstemmed	Programmed cell senescence in skeleton during late puberty
title_sort	programmed cell senescence in skeleton during late puberty
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4a45054ad544440fb6c5efb9d5044ffb
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Programmed cell senescence in skeleton during late puberty

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