Uvulopalatopharyngoplasty may decrease the incidence of Parkinson’s disease associated with obstructive sleep apnea

Abstract The purpose of this study was to investigate whether the incidence of Parkinson’s disease (PD) is increased among patients with obstructive sleep apnea (OSA) and whether surgical treatment can prevent such an increase. This was a retrospective cohort study. We analysed the claims data from...

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Autores principales:	Heung Man Lee, Kyung-Do Han, Jeffrey D. Suh, Jae Hoon Cho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4a45bea4e0cc4641b2a254ea114604af
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spelling	oai:doaj.org-article:4a45bea4e0cc4641b2a254ea114604af2021-12-02T14:29:03ZUvulopalatopharyngoplasty may decrease the incidence of Parkinson’s disease associated with obstructive sleep apnea10.1038/s41598-021-89205-42045-2322https://doaj.org/article/4a45bea4e0cc4641b2a254ea114604af2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89205-4https://doaj.org/toc/2045-2322Abstract The purpose of this study was to investigate whether the incidence of Parkinson’s disease (PD) is increased among patients with obstructive sleep apnea (OSA) and whether surgical treatment can prevent such an increase. This was a retrospective cohort study. We analysed the claims data from the Korea National Health Insurance Service. A total of 202,726 patients who were newly diagnosed with OSA between 2007 and 2014 were included. The patients were divided into two groups: patients who underwent uvulopalatopharyngoplasty (surgery group, n = 22,742) and those who did not (conservative group, n = 179,984). The control group (n = 1,013,630) was selected by propensity score matching. They were tracked until 31st December 2015. The hazard ratio of PD diagnosis (95% confidence interval) in the OSA group with respect to the control group was calculated using the Cox proportional hazard model. In the conservative group, the incidence of PD (hazard ratio 2.57 [2.32–2.85]) was significantly higher than that in the control group, while the incidence of PD in the surgery group was similar to that in the control group (hazard ratio 1.45 [0.89–2.22]). Patients with OSA are at an increased risk of developing PD, and uvulopalatopharyngoplasty may mitigate this risk.Heung Man LeeKyung-Do HanJeffrey D. SuhJae Hoon ChoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Heung Man Lee Kyung-Do Han Jeffrey D. Suh Jae Hoon Cho Uvulopalatopharyngoplasty may decrease the incidence of Parkinson’s disease associated with obstructive sleep apnea
description	Abstract The purpose of this study was to investigate whether the incidence of Parkinson’s disease (PD) is increased among patients with obstructive sleep apnea (OSA) and whether surgical treatment can prevent such an increase. This was a retrospective cohort study. We analysed the claims data from the Korea National Health Insurance Service. A total of 202,726 patients who were newly diagnosed with OSA between 2007 and 2014 were included. The patients were divided into two groups: patients who underwent uvulopalatopharyngoplasty (surgery group, n = 22,742) and those who did not (conservative group, n = 179,984). The control group (n = 1,013,630) was selected by propensity score matching. They were tracked until 31st December 2015. The hazard ratio of PD diagnosis (95% confidence interval) in the OSA group with respect to the control group was calculated using the Cox proportional hazard model. In the conservative group, the incidence of PD (hazard ratio 2.57 [2.32–2.85]) was significantly higher than that in the control group, while the incidence of PD in the surgery group was similar to that in the control group (hazard ratio 1.45 [0.89–2.22]). Patients with OSA are at an increased risk of developing PD, and uvulopalatopharyngoplasty may mitigate this risk.
format	article
author	Heung Man Lee Kyung-Do Han Jeffrey D. Suh Jae Hoon Cho
author_facet	Heung Man Lee Kyung-Do Han Jeffrey D. Suh Jae Hoon Cho
author_sort	Heung Man Lee
title	Uvulopalatopharyngoplasty may decrease the incidence of Parkinson’s disease associated with obstructive sleep apnea
title_short	Uvulopalatopharyngoplasty may decrease the incidence of Parkinson’s disease associated with obstructive sleep apnea
title_full	Uvulopalatopharyngoplasty may decrease the incidence of Parkinson’s disease associated with obstructive sleep apnea
title_fullStr	Uvulopalatopharyngoplasty may decrease the incidence of Parkinson’s disease associated with obstructive sleep apnea
title_full_unstemmed	Uvulopalatopharyngoplasty may decrease the incidence of Parkinson’s disease associated with obstructive sleep apnea
title_sort	uvulopalatopharyngoplasty may decrease the incidence of parkinson’s disease associated with obstructive sleep apnea
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4a45bea4e0cc4641b2a254ea114604af
work_keys_str_mv	AT heungmanlee uvulopalatopharyngoplastymaydecreasetheincidenceofparkinsonsdiseaseassociatedwithobstructivesleepapnea AT kyungdohan uvulopalatopharyngoplastymaydecreasetheincidenceofparkinsonsdiseaseassociatedwithobstructivesleepapnea AT jeffreydsuh uvulopalatopharyngoplastymaydecreasetheincidenceofparkinsonsdiseaseassociatedwithobstructivesleepapnea AT jaehooncho uvulopalatopharyngoplastymaydecreasetheincidenceofparkinsonsdiseaseassociatedwithobstructivesleepapnea
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Uvulopalatopharyngoplasty may decrease the incidence of Parkinson’s disease associated with obstructive sleep apnea

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