Adrenal hormones mediate disease tolerance in malaria

Disease tolerance mechanisms counter the negative effects of infection without decreasing the pathogen load. Here, the authors show that in mouse models of malaria, such disease tolerance can be conferred by adrenal hormones, by preventing excessive inflammation and hypoglycemia.

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Autores principales:	Leen Vandermosten, Thao-Thy Pham, Sofie Knoops, Charlotte De Geest, Natacha Lays, Kristof Van der Molen, Christopher J. Kenyon, Manu Verma, Karen E. Chapman, Frans Schuit, Karolien De Bosscher, Ghislain Opdenakker, Philippe E. Van den Steen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4a46f7525e7d4cd28340e26b10d771de
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spelling	oai:doaj.org-article:4a46f7525e7d4cd28340e26b10d771de2021-12-02T15:34:17ZAdrenal hormones mediate disease tolerance in malaria10.1038/s41467-018-06986-52041-1723https://doaj.org/article/4a46f7525e7d4cd28340e26b10d771de2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06986-5https://doaj.org/toc/2041-1723Disease tolerance mechanisms counter the negative effects of infection without decreasing the pathogen load. Here, the authors show that in mouse models of malaria, such disease tolerance can be conferred by adrenal hormones, by preventing excessive inflammation and hypoglycemia.Leen VandermostenThao-Thy PhamSofie KnoopsCharlotte De GeestNatacha LaysKristof Van der MolenChristopher J. KenyonManu VermaKaren E. ChapmanFrans SchuitKarolien De BosscherGhislain OpdenakkerPhilippe E. Van den SteenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Leen Vandermosten Thao-Thy Pham Sofie Knoops Charlotte De Geest Natacha Lays Kristof Van der Molen Christopher J. Kenyon Manu Verma Karen E. Chapman Frans Schuit Karolien De Bosscher Ghislain Opdenakker Philippe E. Van den Steen Adrenal hormones mediate disease tolerance in malaria
description	Disease tolerance mechanisms counter the negative effects of infection without decreasing the pathogen load. Here, the authors show that in mouse models of malaria, such disease tolerance can be conferred by adrenal hormones, by preventing excessive inflammation and hypoglycemia.
format	article
author	Leen Vandermosten Thao-Thy Pham Sofie Knoops Charlotte De Geest Natacha Lays Kristof Van der Molen Christopher J. Kenyon Manu Verma Karen E. Chapman Frans Schuit Karolien De Bosscher Ghislain Opdenakker Philippe E. Van den Steen
author_facet	Leen Vandermosten Thao-Thy Pham Sofie Knoops Charlotte De Geest Natacha Lays Kristof Van der Molen Christopher J. Kenyon Manu Verma Karen E. Chapman Frans Schuit Karolien De Bosscher Ghislain Opdenakker Philippe E. Van den Steen
author_sort	Leen Vandermosten
title	Adrenal hormones mediate disease tolerance in malaria
title_short	Adrenal hormones mediate disease tolerance in malaria
title_full	Adrenal hormones mediate disease tolerance in malaria
title_fullStr	Adrenal hormones mediate disease tolerance in malaria
title_full_unstemmed	Adrenal hormones mediate disease tolerance in malaria
title_sort	adrenal hormones mediate disease tolerance in malaria
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4a46f7525e7d4cd28340e26b10d771de
work_keys_str_mv	AT leenvandermosten adrenalhormonesmediatediseasetoleranceinmalaria AT thaothypham adrenalhormonesmediatediseasetoleranceinmalaria AT sofieknoops adrenalhormonesmediatediseasetoleranceinmalaria AT charlottedegeest adrenalhormonesmediatediseasetoleranceinmalaria AT natachalays adrenalhormonesmediatediseasetoleranceinmalaria AT kristofvandermolen adrenalhormonesmediatediseasetoleranceinmalaria AT christopherjkenyon adrenalhormonesmediatediseasetoleranceinmalaria AT manuverma adrenalhormonesmediatediseasetoleranceinmalaria AT karenechapman adrenalhormonesmediatediseasetoleranceinmalaria AT fransschuit adrenalhormonesmediatediseasetoleranceinmalaria AT karoliendebosscher adrenalhormonesmediatediseasetoleranceinmalaria AT ghislainopdenakker adrenalhormonesmediatediseasetoleranceinmalaria AT philippeevandensteen adrenalhormonesmediatediseasetoleranceinmalaria
_version_	1718386895990292480

Adrenal hormones mediate disease tolerance in malaria

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