Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling

Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling

Long non-coding RNAs (lncRNA) are known to regulate human embryonic stem cell (hESC) self-renewal. Here, the authors identify lncRNA growth-arrest-specific transcript 5 (GAS5) that regulates pluripotency via modulation of NODAL signalling to maintain self-renewal in hESCs.

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Autores principales: Chen Xu, Yan Zhang, Qiaoling Wang, Zhenyu Xu, Junfeng Jiang, Yuping Gao, Minzhi Gao, Jiuhong Kang, Minjuan Wu, Jun Xiong, Kaihong Ji, Wen Yuan, Yue Wang, Houqi Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/4a477c78d24844d0ad0f74749c74c2ce
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spelling oai:doaj.org-article:4a477c78d24844d0ad0f74749c74c2ce2021-12-02T17:33:19ZLong non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling10.1038/ncomms132872041-1723https://doaj.org/article/4a477c78d24844d0ad0f74749c74c2ce2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13287https://doaj.org/toc/2041-1723Long non-coding RNAs (lncRNA) are known to regulate human embryonic stem cell (hESC) self-renewal. Here, the authors identify lncRNA growth-arrest-specific transcript 5 (GAS5) that regulates pluripotency via modulation of NODAL signalling to maintain self-renewal in hESCs.Chen XuYan ZhangQiaoling WangZhenyu XuJunfeng JiangYuping GaoMinzhi GaoJiuhong KangMinjuan WuJun XiongKaihong JiWen YuanYue WangHouqi LiuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chen Xu
Yan Zhang
Qiaoling Wang
Zhenyu Xu
Junfeng Jiang
Yuping Gao
Minzhi Gao
Jiuhong Kang
Minjuan Wu
Jun Xiong
Kaihong Ji
Wen Yuan
Yue Wang
Houqi Liu
Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling
description Long non-coding RNAs (lncRNA) are known to regulate human embryonic stem cell (hESC) self-renewal. Here, the authors identify lncRNA growth-arrest-specific transcript 5 (GAS5) that regulates pluripotency via modulation of NODAL signalling to maintain self-renewal in hESCs.
format article
author Chen Xu
Yan Zhang
Qiaoling Wang
Zhenyu Xu
Junfeng Jiang
Yuping Gao
Minzhi Gao
Jiuhong Kang
Minjuan Wu
Jun Xiong
Kaihong Ji
Wen Yuan
Yue Wang
Houqi Liu
author_facet Chen Xu
Yan Zhang
Qiaoling Wang
Zhenyu Xu
Junfeng Jiang
Yuping Gao
Minzhi Gao
Jiuhong Kang
Minjuan Wu
Jun Xiong
Kaihong Ji
Wen Yuan
Yue Wang
Houqi Liu
author_sort Chen Xu
title Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling
title_short Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling
title_full Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling
title_fullStr Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling
title_full_unstemmed Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling
title_sort long non-coding rna gas5 controls human embryonic stem cell self-renewal by maintaining nodal signalling
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/4a477c78d24844d0ad0f74749c74c2ce
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