<i>Enterococcus faecium</i> Regulates Honey Bee Developmental Genes

Honey bees provide essential pollination services to the terrestrial ecosystem and produce important agricultural products. As a beneficial lactic acid bacterium, <i>Enterococcus faecium</i> is often supplied as a probiotic for honey bees and other animals. However, the underlying mechan...

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Autores principales:	Yating Du, Shiqi Luo, Xin Zhou
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Enterococcus faecium</i> gut bacteria honey bee miRNA transcriptome Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/4a497fa4a3d74b1fb296698e6d55cb33
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spelling	oai:doaj.org-article:4a497fa4a3d74b1fb296698e6d55cb332021-11-25T17:53:27Z<i>Enterococcus faecium</i> Regulates Honey Bee Developmental Genes10.3390/ijms2222121051422-00671661-6596https://doaj.org/article/4a497fa4a3d74b1fb296698e6d55cb332021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12105https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Honey bees provide essential pollination services to the terrestrial ecosystem and produce important agricultural products. As a beneficial lactic acid bacterium, <i>Enterococcus faecium</i> is often supplied as a probiotic for honey bees and other animals. However, the underlying mechanisms of its actions and possible safety risks are not well understood. We present the first complete genome sequence of <i>E. faecium</i> isolated from the honey bee gut using nanopore sequencing, and investigate the effects and mechanisms of interactions between <i>E. faecium</i> and honey bees via transcriptome and miRNA analysis. <i>E. faecium</i> colonization increased honey bee gut weight. Transcriptome analysis showed that developmental genes were up-regulated. In accordance, the target genes of the down-regulated miRNAs were enriched in developmental pathways. We describe how <i>E. faecium</i> increases honey bee gut weight at the transcriptional and post-transcriptional levels, and add insights about how miRNAs mediate host and bacteria interactions.Yating DuShiqi LuoXin ZhouMDPI AGarticle<i>Enterococcus faecium</i>gut bacteriahoney beemiRNAtranscriptomeBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12105, p 12105 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Enterococcus faecium</i> gut bacteria honey bee miRNA transcriptome Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	<i>Enterococcus faecium</i> gut bacteria honey bee miRNA transcriptome Biology (General) QH301-705.5 Chemistry QD1-999 Yating Du Shiqi Luo Xin Zhou <i>Enterococcus faecium</i> Regulates Honey Bee Developmental Genes
description	Honey bees provide essential pollination services to the terrestrial ecosystem and produce important agricultural products. As a beneficial lactic acid bacterium, <i>Enterococcus faecium</i> is often supplied as a probiotic for honey bees and other animals. However, the underlying mechanisms of its actions and possible safety risks are not well understood. We present the first complete genome sequence of <i>E. faecium</i> isolated from the honey bee gut using nanopore sequencing, and investigate the effects and mechanisms of interactions between <i>E. faecium</i> and honey bees via transcriptome and miRNA analysis. <i>E. faecium</i> colonization increased honey bee gut weight. Transcriptome analysis showed that developmental genes were up-regulated. In accordance, the target genes of the down-regulated miRNAs were enriched in developmental pathways. We describe how <i>E. faecium</i> increases honey bee gut weight at the transcriptional and post-transcriptional levels, and add insights about how miRNAs mediate host and bacteria interactions.
format	article
author	Yating Du Shiqi Luo Xin Zhou
author_facet	Yating Du Shiqi Luo Xin Zhou
author_sort	Yating Du
title	<i>Enterococcus faecium</i> Regulates Honey Bee Developmental Genes
title_short	<i>Enterococcus faecium</i> Regulates Honey Bee Developmental Genes
title_full	<i>Enterococcus faecium</i> Regulates Honey Bee Developmental Genes
title_fullStr	<i>Enterococcus faecium</i> Regulates Honey Bee Developmental Genes
title_full_unstemmed	<i>Enterococcus faecium</i> Regulates Honey Bee Developmental Genes
title_sort	<i>enterococcus faecium</i> regulates honey bee developmental genes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4a497fa4a3d74b1fb296698e6d55cb33
work_keys_str_mv	AT yatingdu ienterococcusfaeciumiregulateshoneybeedevelopmentalgenes AT shiqiluo ienterococcusfaeciumiregulateshoneybeedevelopmentalgenes AT xinzhou ienterococcusfaeciumiregulateshoneybeedevelopmentalgenes
_version_	1718411859637305344

<i>Enterococcus faecium</i> Regulates Honey Bee Developmental Genes

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