SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice

SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice

Here, the authors characterize a SARS-CoV-2 subunit vaccine candidate that contains full-length spike protein stabilized in its prefusion conformation, and show immunogenicity in baboons and protection in mice with Matrix-M adjuvanted vaccine.

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Autores principales: Jing-Hui Tian, Nita Patel, Robert Haupt, Haixia Zhou, Stuart Weston, Holly Hammond, James Logue, Alyse D. Portnoff, James Norton, Mimi Guebre-Xabier, Bin Zhou, Kelsey Jacobson, Sonia Maciejewski, Rafia Khatoon, Malgorzata Wisniewska, Will Moffitt, Stefanie Kluepfel-Stahl, Betty Ekechukwu, James Papin, Sarathi Boddapati, C. Jason Wong, Pedro A. Piedra, Matthew B. Frieman, Michael J. Massare, Louis Fries, Karin Lövgren Bengtsson, Linda Stertman, Larry Ellingsworth, Gregory Glenn, Gale Smith
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/4a4e382fc93a4e5c84f3c4b94fc40a65
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spelling oai:doaj.org-article:4a4e382fc93a4e5c84f3c4b94fc40a652021-12-02T14:01:14ZSARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice10.1038/s41467-020-20653-82041-1723https://doaj.org/article/4a4e382fc93a4e5c84f3c4b94fc40a652021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20653-8https://doaj.org/toc/2041-1723Here, the authors characterize a SARS-CoV-2 subunit vaccine candidate that contains full-length spike protein stabilized in its prefusion conformation, and show immunogenicity in baboons and protection in mice with Matrix-M adjuvanted vaccine.Jing-Hui TianNita PatelRobert HauptHaixia ZhouStuart WestonHolly HammondJames LogueAlyse D. PortnoffJames NortonMimi Guebre-XabierBin ZhouKelsey JacobsonSonia MaciejewskiRafia KhatoonMalgorzata WisniewskaWill MoffittStefanie Kluepfel-StahlBetty EkechukwuJames PapinSarathi BoddapatiC. Jason WongPedro A. PiedraMatthew B. FriemanMichael J. MassareLouis FriesKarin Lövgren BengtssonLinda StertmanLarry EllingsworthGregory GlennGale SmithNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jing-Hui Tian
Nita Patel
Robert Haupt
Haixia Zhou
Stuart Weston
Holly Hammond
James Logue
Alyse D. Portnoff
James Norton
Mimi Guebre-Xabier
Bin Zhou
Kelsey Jacobson
Sonia Maciejewski
Rafia Khatoon
Malgorzata Wisniewska
Will Moffitt
Stefanie Kluepfel-Stahl
Betty Ekechukwu
James Papin
Sarathi Boddapati
C. Jason Wong
Pedro A. Piedra
Matthew B. Frieman
Michael J. Massare
Louis Fries
Karin Lövgren Bengtsson
Linda Stertman
Larry Ellingsworth
Gregory Glenn
Gale Smith
SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice
description Here, the authors characterize a SARS-CoV-2 subunit vaccine candidate that contains full-length spike protein stabilized in its prefusion conformation, and show immunogenicity in baboons and protection in mice with Matrix-M adjuvanted vaccine.
format article
author Jing-Hui Tian
Nita Patel
Robert Haupt
Haixia Zhou
Stuart Weston
Holly Hammond
James Logue
Alyse D. Portnoff
James Norton
Mimi Guebre-Xabier
Bin Zhou
Kelsey Jacobson
Sonia Maciejewski
Rafia Khatoon
Malgorzata Wisniewska
Will Moffitt
Stefanie Kluepfel-Stahl
Betty Ekechukwu
James Papin
Sarathi Boddapati
C. Jason Wong
Pedro A. Piedra
Matthew B. Frieman
Michael J. Massare
Louis Fries
Karin Lövgren Bengtsson
Linda Stertman
Larry Ellingsworth
Gregory Glenn
Gale Smith
author_facet Jing-Hui Tian
Nita Patel
Robert Haupt
Haixia Zhou
Stuart Weston
Holly Hammond
James Logue
Alyse D. Portnoff
James Norton
Mimi Guebre-Xabier
Bin Zhou
Kelsey Jacobson
Sonia Maciejewski
Rafia Khatoon
Malgorzata Wisniewska
Will Moffitt
Stefanie Kluepfel-Stahl
Betty Ekechukwu
James Papin
Sarathi Boddapati
C. Jason Wong
Pedro A. Piedra
Matthew B. Frieman
Michael J. Massare
Louis Fries
Karin Lövgren Bengtsson
Linda Stertman
Larry Ellingsworth
Gregory Glenn
Gale Smith
author_sort Jing-Hui Tian
title SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice
title_short SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice
title_full SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice
title_fullStr SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice
title_full_unstemmed SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice
title_sort sars-cov-2 spike glycoprotein vaccine candidate nvx-cov2373 immunogenicity in baboons and protection in mice
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/4a4e382fc93a4e5c84f3c4b94fc40a65
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