Parallel modulation of intracortical excitability of somatosensory and visual cortex by the gonadal hormones estradiol and progesterone
Abstract The levels of the gonadal hormones estradiol and progesterone vary throughout the menstrual cycle thereby affecting cognition, emotion, mood, and social behaviour. However, how these hormones modulate the balance of neural excitation and inhibition, which crucially regulate processing and p...
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Nature Portfolio
2020
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oai:doaj.org-article:4a4eabbf050945fa99e3f1a553d87e932021-12-02T12:40:40ZParallel modulation of intracortical excitability of somatosensory and visual cortex by the gonadal hormones estradiol and progesterone10.1038/s41598-020-79389-62045-2322https://doaj.org/article/4a4eabbf050945fa99e3f1a553d87e932020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79389-6https://doaj.org/toc/2045-2322Abstract The levels of the gonadal hormones estradiol and progesterone vary throughout the menstrual cycle thereby affecting cognition, emotion, mood, and social behaviour. However, how these hormones modulate the balance of neural excitation and inhibition, which crucially regulate processing and plasticity, is not fully understood. We here used paired-pulse stimulation to investigate in healthy humans the action of low and high estradiol and progesterone on intracortical inhibition in somatosensory (SI) and visual cortex (V1). We found that paired-pulse suppression in both SI and VI depended on estradiol. During high estradiol levels, paired-pulse suppression was significantly reduced. No comparable effects were found for progesterone, presumably due to a confounding effect of estradiol. Also, no hormone level-depending effects were observed for single-pulse evoked SEPs (somatosensory evoked potentials) and VEPs (visual evoked potentials) indicating a specific hormonal action on intracortical processing. The results demonstrate that estradiol globally modulates the balance of excitation and inhibition of SI and VI cortex.Nasim SchloemerMelanie LenzMartin TegenthoffHubert R. DinseOliver HöffkenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020) |
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Medicine R Science Q |
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Medicine R Science Q Nasim Schloemer Melanie Lenz Martin Tegenthoff Hubert R. Dinse Oliver Höffken Parallel modulation of intracortical excitability of somatosensory and visual cortex by the gonadal hormones estradiol and progesterone |
| description |
Abstract The levels of the gonadal hormones estradiol and progesterone vary throughout the menstrual cycle thereby affecting cognition, emotion, mood, and social behaviour. However, how these hormones modulate the balance of neural excitation and inhibition, which crucially regulate processing and plasticity, is not fully understood. We here used paired-pulse stimulation to investigate in healthy humans the action of low and high estradiol and progesterone on intracortical inhibition in somatosensory (SI) and visual cortex (V1). We found that paired-pulse suppression in both SI and VI depended on estradiol. During high estradiol levels, paired-pulse suppression was significantly reduced. No comparable effects were found for progesterone, presumably due to a confounding effect of estradiol. Also, no hormone level-depending effects were observed for single-pulse evoked SEPs (somatosensory evoked potentials) and VEPs (visual evoked potentials) indicating a specific hormonal action on intracortical processing. The results demonstrate that estradiol globally modulates the balance of excitation and inhibition of SI and VI cortex. |
| format |
article |
| author |
Nasim Schloemer Melanie Lenz Martin Tegenthoff Hubert R. Dinse Oliver Höffken |
| author_facet |
Nasim Schloemer Melanie Lenz Martin Tegenthoff Hubert R. Dinse Oliver Höffken |
| author_sort |
Nasim Schloemer |
| title |
Parallel modulation of intracortical excitability of somatosensory and visual cortex by the gonadal hormones estradiol and progesterone |
| title_short |
Parallel modulation of intracortical excitability of somatosensory and visual cortex by the gonadal hormones estradiol and progesterone |
| title_full |
Parallel modulation of intracortical excitability of somatosensory and visual cortex by the gonadal hormones estradiol and progesterone |
| title_fullStr |
Parallel modulation of intracortical excitability of somatosensory and visual cortex by the gonadal hormones estradiol and progesterone |
| title_full_unstemmed |
Parallel modulation of intracortical excitability of somatosensory and visual cortex by the gonadal hormones estradiol and progesterone |
| title_sort |
parallel modulation of intracortical excitability of somatosensory and visual cortex by the gonadal hormones estradiol and progesterone |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/4a4eabbf050945fa99e3f1a553d87e93 |
| work_keys_str_mv |
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