The onset of rheumatoid arthritis following trauma

Arthur E Brawer, Noopur Goel Department of Medicine, Monmouth Medical Center, Long Branch, NJ, USA Background: Rheumatoid arthritis (RA) is known to have many predisposing factors.Objective: We studied individuals whose RA was initiated by physical injuries.Patients and methods: Sixty patie...

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Autores principales:	Brawer AE, Goel N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Trauma rheumatoid arthritis injuries Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/4a512d05687947bc831f269f55db009c
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spelling	oai:doaj.org-article:4a512d05687947bc831f269f55db009c2021-12-02T01:07:24ZThe onset of rheumatoid arthritis following trauma1179-156Xhttps://doaj.org/article/4a512d05687947bc831f269f55db009c2016-08-01T00:00:00Zhttps://www.dovepress.com/the-onset-of-rheumatoid-arthritis-following-trauma-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XArthur E Brawer, Noopur Goel Department of Medicine, Monmouth Medical Center, Long Branch, NJ, USA Background: Rheumatoid arthritis (RA) is known to have many predisposing factors.Objective: We studied individuals whose RA was initiated by physical injuries.Patients and methods: Sixty patients (43 females), previously well, developed RA following trauma. No other known environmental or familial influences were present. Fourteen sustained a fracture; of the 46 who did not, 36 sustained multiple injuries that in part involved the axial skeleton. Subsequent unremitting daily pain, stiffness, limited motion, pain on motion, and/or swelling in the injured areas were mandatory for inclusion.Results: Nine months after injuries (span: 2 weeks–36 months), more obvious signs of inflammation (IM) appeared in multiple other joints that were previously not affected by the original trauma. In those with laboratory tests done prior to the spread of IM (30/60), 22 (73%) were normal until an average 8 months after the spread of IM. Of the entire cohort of 60, only 23% had a positive rheumatoid factor, but 43% had a positive antinuclear antibody.Conclusion: It seems apparent that any severe trauma to a joint may precipitate an ongoing localized chronic inflammatory disorder for an indefinite period of time, which may then lead to the spread of IM to multiple other joints. The initiation of RA following trauma warrants consideration as a legitimate entity. Keywords: rheumatoid arthritis, trauma, injuries, inflammation, antinuclear antibody, rheumatoid factorBrawer AEGoel NDove Medical PressarticleTraumarheumatoid arthritisinjuriesDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 8, Pp 77-80 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Trauma rheumatoid arthritis injuries Diseases of the musculoskeletal system RC925-935
spellingShingle	Trauma rheumatoid arthritis injuries Diseases of the musculoskeletal system RC925-935 Brawer AE Goel N The onset of rheumatoid arthritis following trauma
description	Arthur E Brawer, Noopur Goel Department of Medicine, Monmouth Medical Center, Long Branch, NJ, USA Background: Rheumatoid arthritis (RA) is known to have many predisposing factors.Objective: We studied individuals whose RA was initiated by physical injuries.Patients and methods: Sixty patients (43 females), previously well, developed RA following trauma. No other known environmental or familial influences were present. Fourteen sustained a fracture; of the 46 who did not, 36 sustained multiple injuries that in part involved the axial skeleton. Subsequent unremitting daily pain, stiffness, limited motion, pain on motion, and/or swelling in the injured areas were mandatory for inclusion.Results: Nine months after injuries (span: 2 weeks–36 months), more obvious signs of inflammation (IM) appeared in multiple other joints that were previously not affected by the original trauma. In those with laboratory tests done prior to the spread of IM (30/60), 22 (73%) were normal until an average 8 months after the spread of IM. Of the entire cohort of 60, only 23% had a positive rheumatoid factor, but 43% had a positive antinuclear antibody.Conclusion: It seems apparent that any severe trauma to a joint may precipitate an ongoing localized chronic inflammatory disorder for an indefinite period of time, which may then lead to the spread of IM to multiple other joints. The initiation of RA following trauma warrants consideration as a legitimate entity. Keywords: rheumatoid arthritis, trauma, injuries, inflammation, antinuclear antibody, rheumatoid factor
format	article
author	Brawer AE Goel N
author_facet	Brawer AE Goel N
author_sort	Brawer AE
title	The onset of rheumatoid arthritis following trauma
title_short	The onset of rheumatoid arthritis following trauma
title_full	The onset of rheumatoid arthritis following trauma
title_fullStr	The onset of rheumatoid arthritis following trauma
title_full_unstemmed	The onset of rheumatoid arthritis following trauma
title_sort	onset of rheumatoid arthritis following trauma
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/4a512d05687947bc831f269f55db009c
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The onset of rheumatoid arthritis following trauma

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