Extra! Extracellular Effector Delivery into Host Cells via the Type 3 Secretion System

ABSTRACT The type three secretion system (T3SS) is critical for the virulence of diverse bacterial pathogens. Pathogens use the T3SS to deliver effector proteins into host cells and manipulate host signaling pathways. The prevailing mechanism is that effectors translocate from inside the T3SS direct...

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Autor principal:	Melissa M. Kendall
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	EPEC effectors secretion systems Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/4a5342d02b7a4ecd85fe9824435b6209
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id	oai:doaj.org-article:4a5342d02b7a4ecd85fe9824435b6209
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spelling	oai:doaj.org-article:4a5342d02b7a4ecd85fe9824435b62092021-11-15T15:51:30ZExtra! Extracellular Effector Delivery into Host Cells via the Type 3 Secretion System10.1128/mBio.00594-172150-7511https://doaj.org/article/4a5342d02b7a4ecd85fe9824435b62092017-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00594-17https://doaj.org/toc/2150-7511ABSTRACT The type three secretion system (T3SS) is critical for the virulence of diverse bacterial pathogens. Pathogens use the T3SS to deliver effector proteins into host cells and manipulate host signaling pathways. The prevailing mechanism is that effectors translocate from inside the T3SS directly into the host cell. Recent studies reveal an alternative mechanism of effector translocation, in which an effector protein located outside the bacterial cell relies on the T3SS for delivery into host cells. Tejeda-Dominguez et al. (F. Tejeda-Dominguez, J. Huerta-Cantillo, L. Chavez-Dueñas, and F. Navarro-Garcia, mBio 8:e00184-17, 2017, https://doi.org/10.1128/mBio.00184-17 ) demonstrate that the EspC effector of enteropathogenic Escherichia coli is translocated by binding to the outside of the T3SS and subsequently gains access to the host cell cytoplasm through the T3SS pore embedded within the host cell membrane. This work reveals a novel mechanism of translocation that is likely relevant for a variety of other pathogens that use the T3SS as part of their virulence arsenal.Melissa M. KendallAmerican Society for MicrobiologyarticleEPECeffectorssecretion systemsMicrobiologyQR1-502ENmBio, Vol 8, Iss 3 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	EPEC effectors secretion systems Microbiology QR1-502
spellingShingle	EPEC effectors secretion systems Microbiology QR1-502 Melissa M. Kendall Extra! Extracellular Effector Delivery into Host Cells via the Type 3 Secretion System
description	ABSTRACT The type three secretion system (T3SS) is critical for the virulence of diverse bacterial pathogens. Pathogens use the T3SS to deliver effector proteins into host cells and manipulate host signaling pathways. The prevailing mechanism is that effectors translocate from inside the T3SS directly into the host cell. Recent studies reveal an alternative mechanism of effector translocation, in which an effector protein located outside the bacterial cell relies on the T3SS for delivery into host cells. Tejeda-Dominguez et al. (F. Tejeda-Dominguez, J. Huerta-Cantillo, L. Chavez-Dueñas, and F. Navarro-Garcia, mBio 8:e00184-17, 2017, https://doi.org/10.1128/mBio.00184-17 ) demonstrate that the EspC effector of enteropathogenic Escherichia coli is translocated by binding to the outside of the T3SS and subsequently gains access to the host cell cytoplasm through the T3SS pore embedded within the host cell membrane. This work reveals a novel mechanism of translocation that is likely relevant for a variety of other pathogens that use the T3SS as part of their virulence arsenal.
format	article
author	Melissa M. Kendall
author_facet	Melissa M. Kendall
author_sort	Melissa M. Kendall
title	Extra! Extracellular Effector Delivery into Host Cells via the Type 3 Secretion System
title_short	Extra! Extracellular Effector Delivery into Host Cells via the Type 3 Secretion System
title_full	Extra! Extracellular Effector Delivery into Host Cells via the Type 3 Secretion System
title_fullStr	Extra! Extracellular Effector Delivery into Host Cells via the Type 3 Secretion System
title_full_unstemmed	Extra! Extracellular Effector Delivery into Host Cells via the Type 3 Secretion System
title_sort	extra! extracellular effector delivery into host cells via the type 3 secretion system
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/4a5342d02b7a4ecd85fe9824435b6209
work_keys_str_mv	AT melissamkendall extraextracellulareffectordeliveryintohostcellsviathetype3secretionsystem
_version_	1718427332617699328

Extra! Extracellular Effector Delivery into Host Cells via the Type 3 Secretion System

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