UBCH5 Family Members Differentially Impact Stabilization of Mutant p53 via RNF128 Iso1 During Barrett’s Progression to Esophageal AdenocarcinomaSummary

UBCH5 Family Members Differentially Impact Stabilization of Mutant p53 via RNF128 Iso1 During Barrett’s Progression to Esophageal AdenocarcinomaSummary

Background & Aims: TP53 mutations underlie Barrett’s esophagus (BE) progression to dysplasia and cancer. During BE progression, the ubiquitin ligase (E3) RNF128/GRAIL switches expression from isoform 2 (Iso2) to Iso1, stabilizing mutant p53. However, the ubiquitin-conjugating enzyme (E2) tha...

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Autores principales: Paramita Ray, Derek J. Nancarrow, Daysha Ferrer-Torres, Zhuwen Wang, May San Martinho, Tonaye Hinton, Joshua H. Wu, Angeline Wu, Danielle Kim Turgeon, Max A. Hammer, Michael K. Dame, Theodore S. Lawrence, Patrick J. O’Brien, Jason R. Spence, David G. Beer, Dipankar Ray
Formato: article
Lenguaje:EN
Publicado: Elsevier 2022
Materias:
Barrett’s Esophagus
Esophageal Adenocarcinoma
RNF128-UBCH5 Complex
p53 Protein Stability
Diseases of the digestive system. Gastroenterology
RC799-869
Acceso en línea:https://doaj.org/article/4a56ad18c7804a3bbc16ac9b32c78f2e
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