Purified F-ATP synthase forms a Ca2+-dependent high-conductance channel matching the mitochondrial permeability transition pore

The molecular identity of the mitochondrial megachannel (MMC)/permeability transition pore (PTP), a key effector of cell death, remains controversial. Here authors demonstrate that the membrane embedded bovine F-ATP synthase elicits Ca2 + -dependent currents matching those of the MMC/PTP.

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Detalles Bibliográficos
Autores principales:	Andrea Urbani, Valentina Giorgio, Andrea Carrer, Cinzia Franchin, Giorgio Arrigoni, Chimari Jiko, Kazuhiro Abe, Shintaro Maeda, Kyoko Shinzawa-Itoh, Janna F. M. Bogers, Duncan G. G. McMillan, Christoph Gerle, Ildikò Szabò, Paolo Bernardi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4a5ef2a2afab45b2bd9dd7713ba29e76
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Purified F-ATP synthase forms a Ca2+-dependent high-conductance channel matching the mitochondrial permeability transition pore

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