A system-level investigation into the mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for cardiovascular disease treatment.
Compound Danshen Formula (CDF) is a widely used Traditional Chinese Medicine (TCM) which has been extensively applied in clinical treatment of cardiovascular diseases (CVDs). However, the underlying mechanism of clinical administrating CDF on CVDs is not clear. In this study, the pharmacological eff...
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Public Library of Science (PLoS)
2012
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oai:doaj.org-article:4a6522f0ed4c42eeaae14f0aec1ddab02021-11-18T07:06:45ZA system-level investigation into the mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for cardiovascular disease treatment.1932-620310.1371/journal.pone.0043918https://doaj.org/article/4a6522f0ed4c42eeaae14f0aec1ddab02012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22962593/?tool=EBIhttps://doaj.org/toc/1932-6203Compound Danshen Formula (CDF) is a widely used Traditional Chinese Medicine (TCM) which has been extensively applied in clinical treatment of cardiovascular diseases (CVDs). However, the underlying mechanism of clinical administrating CDF on CVDs is not clear. In this study, the pharmacological effect of CDF on CVDs was analyzed at a systemic point of view. A systems-pharmacological model based on chemical, chemogenomics and pharmacological data is developed via network reconstruction approach. By using this model, we performed a high-throughput in silico screen and obtained a group of compounds from CDF which possess desirable pharmacodynamical and pharmacological characteristics. These compounds and the corresponding protein targets are further used to search against biological databases, such as the compound-target associations, compound-pathway connections and disease-target interactions for reconstructing the biologically meaningful networks for a TCM formula. This study not only made a contribution to a better understanding of the mechanisms of CDF, but also proposed a strategy to develop novel TCM candidates at a network pharmacology level.Xiuxiu LiXue XuJinan WangHua YuXia WangHongjun YangHaiyu XuShihuan TangYan LiLing YangLuqi HuangYonghua WangShengli YangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e43918 (2012) |
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DOAJ |
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DOAJ |
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EN |
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Medicine R Science Q |
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Medicine R Science Q Xiuxiu Li Xue Xu Jinan Wang Hua Yu Xia Wang Hongjun Yang Haiyu Xu Shihuan Tang Yan Li Ling Yang Luqi Huang Yonghua Wang Shengli Yang A system-level investigation into the mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for cardiovascular disease treatment. |
| description |
Compound Danshen Formula (CDF) is a widely used Traditional Chinese Medicine (TCM) which has been extensively applied in clinical treatment of cardiovascular diseases (CVDs). However, the underlying mechanism of clinical administrating CDF on CVDs is not clear. In this study, the pharmacological effect of CDF on CVDs was analyzed at a systemic point of view. A systems-pharmacological model based on chemical, chemogenomics and pharmacological data is developed via network reconstruction approach. By using this model, we performed a high-throughput in silico screen and obtained a group of compounds from CDF which possess desirable pharmacodynamical and pharmacological characteristics. These compounds and the corresponding protein targets are further used to search against biological databases, such as the compound-target associations, compound-pathway connections and disease-target interactions for reconstructing the biologically meaningful networks for a TCM formula. This study not only made a contribution to a better understanding of the mechanisms of CDF, but also proposed a strategy to develop novel TCM candidates at a network pharmacology level. |
| format |
article |
| author |
Xiuxiu Li Xue Xu Jinan Wang Hua Yu Xia Wang Hongjun Yang Haiyu Xu Shihuan Tang Yan Li Ling Yang Luqi Huang Yonghua Wang Shengli Yang |
| author_facet |
Xiuxiu Li Xue Xu Jinan Wang Hua Yu Xia Wang Hongjun Yang Haiyu Xu Shihuan Tang Yan Li Ling Yang Luqi Huang Yonghua Wang Shengli Yang |
| author_sort |
Xiuxiu Li |
| title |
A system-level investigation into the mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for cardiovascular disease treatment. |
| title_short |
A system-level investigation into the mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for cardiovascular disease treatment. |
| title_full |
A system-level investigation into the mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for cardiovascular disease treatment. |
| title_fullStr |
A system-level investigation into the mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for cardiovascular disease treatment. |
| title_full_unstemmed |
A system-level investigation into the mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for cardiovascular disease treatment. |
| title_sort |
system-level investigation into the mechanisms of chinese traditional medicine: compound danshen formula for cardiovascular disease treatment. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/4a6522f0ed4c42eeaae14f0aec1ddab0 |
| work_keys_str_mv |
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