The association between CD157/BST1 polymorphisms and the susceptibility of Parkinson’s disease: a meta-analysis
Jianming Li,1–3 Jia Luo,2 Li Liu,2 Hui Fu,2,3 Liang Tang21Department of Neurology, Xiang-ya Hospital, Central South University, Changsha 410219, People’s Republic of China; 2Department of Human Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical Univers...
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Dove Medical Press
2019
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oai:doaj.org-article:4a68a59c9bfc4d19866a673a38c40ae32021-12-02T06:31:21ZThe association between CD157/BST1 polymorphisms and the susceptibility of Parkinson’s disease: a meta-analysis1178-2021https://doaj.org/article/4a68a59c9bfc4d19866a673a38c40ae32019-04-01T00:00:00Zhttps://www.dovepress.com/the-association-between-cd157bst1-polymorphisms-and-the-susceptibility-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jianming Li,1–3 Jia Luo,2 Li Liu,2 Hui Fu,2,3 Liang Tang21Department of Neurology, Xiang-ya Hospital, Central South University, Changsha 410219, People’s Republic of China; 2Department of Human Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha, 410219, People’s Republic of China; 3Department of Human Anatomy, School of Basic Medical Science, Changsha Medical University, Changsha, 410219, People’s Republic of ChinaBackground: Different studies have provided some evidence for the association between BST1 polymorphisms and Parkinson’s disease (PD). The extent to which these genetic effects are consistent across different populations is unknown.Methods: A meta-analysis of PD case-control studies using a common set of three variants was conducted. Published reports were obtained from electronic databases including Pubmed, Embase, Chinese National Knowledge Infrastructure (CNKI) and Cochrane Library databases between August 2010 and January 2018.Results: A total of 11 individual studies with 8,725 cases and 17,079 controls were included. The results showed statistically significant association between the dominant model of rs11931532 and PD risk in Asian populations (P=0.006, OR [95% CI]=1.22 [1.06–1.41]). Significant association was also detected between the allelic, dominant, and recessive models of rs4698412 and PD risk in Asian populations (allelic model: P<0.00001, OR [95% CI]=1.22 [1.16–1.29]; dominant model: P<0.00001, OR [95%CI]=1.35 [1.20–1.52]; recessive model; P=0.0003, OR [95% CI]=1.30 [1.13–1.50]). Nevertheless, the pooled analyses suggested that no significant association was uncovered between rs11724635 and PD risk (P>0.05).Conclusion: The meta-analysis suggests that the rs11931532 and rs4698412, but not rs11724635 might be risk factors for PD in Asian populations.Keywords: BST1, Parkinson’s disease, polymorphisms, risk factorLi JLuo JLiu LFu HTang LDove Medical PressarticleBST1Parkinson’s diseasePolymorphismsRisk factorNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 1089-1102 (2019) |
| institution |
DOAJ |
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DOAJ |
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EN |
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BST1 Parkinson’s disease Polymorphisms Risk factor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
BST1 Parkinson’s disease Polymorphisms Risk factor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Li J Luo J Liu L Fu H Tang L The association between CD157/BST1 polymorphisms and the susceptibility of Parkinson’s disease: a meta-analysis |
| description |
Jianming Li,1–3 Jia Luo,2 Li Liu,2 Hui Fu,2,3 Liang Tang21Department of Neurology, Xiang-ya Hospital, Central South University, Changsha 410219, People’s Republic of China; 2Department of Human Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha, 410219, People’s Republic of China; 3Department of Human Anatomy, School of Basic Medical Science, Changsha Medical University, Changsha, 410219, People’s Republic of ChinaBackground: Different studies have provided some evidence for the association between BST1 polymorphisms and Parkinson’s disease (PD). The extent to which these genetic effects are consistent across different populations is unknown.Methods: A meta-analysis of PD case-control studies using a common set of three variants was conducted. Published reports were obtained from electronic databases including Pubmed, Embase, Chinese National Knowledge Infrastructure (CNKI) and Cochrane Library databases between August 2010 and January 2018.Results: A total of 11 individual studies with 8,725 cases and 17,079 controls were included. The results showed statistically significant association between the dominant model of rs11931532 and PD risk in Asian populations (P=0.006, OR [95% CI]=1.22 [1.06–1.41]). Significant association was also detected between the allelic, dominant, and recessive models of rs4698412 and PD risk in Asian populations (allelic model: P<0.00001, OR [95% CI]=1.22 [1.16–1.29]; dominant model: P<0.00001, OR [95%CI]=1.35 [1.20–1.52]; recessive model; P=0.0003, OR [95% CI]=1.30 [1.13–1.50]). Nevertheless, the pooled analyses suggested that no significant association was uncovered between rs11724635 and PD risk (P>0.05).Conclusion: The meta-analysis suggests that the rs11931532 and rs4698412, but not rs11724635 might be risk factors for PD in Asian populations.Keywords: BST1, Parkinson’s disease, polymorphisms, risk factor |
| format |
article |
| author |
Li J Luo J Liu L Fu H Tang L |
| author_facet |
Li J Luo J Liu L Fu H Tang L |
| author_sort |
Li J |
| title |
The association between CD157/BST1 polymorphisms and the susceptibility of Parkinson’s disease: a meta-analysis |
| title_short |
The association between CD157/BST1 polymorphisms and the susceptibility of Parkinson’s disease: a meta-analysis |
| title_full |
The association between CD157/BST1 polymorphisms and the susceptibility of Parkinson’s disease: a meta-analysis |
| title_fullStr |
The association between CD157/BST1 polymorphisms and the susceptibility of Parkinson’s disease: a meta-analysis |
| title_full_unstemmed |
The association between CD157/BST1 polymorphisms and the susceptibility of Parkinson’s disease: a meta-analysis |
| title_sort |
association between cd157/bst1 polymorphisms and the susceptibility of parkinson’s disease: a meta-analysis |
| publisher |
Dove Medical Press |
| publishDate |
2019 |
| url |
https://doaj.org/article/4a68a59c9bfc4d19866a673a38c40ae3 |
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