Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis

Despite being an important cancer drug target, the role of epigenetic reader Brd4 in cell differentiation and development remains unclear. Here, the authors provide evidence that Brd4 plays an important role in adipogenesis and myogenesis by binding to active enhancers to regulate gene expression.

Guardado en:

Detalles Bibliográficos
Autores principales:	Ji-Eun Lee, Young-Kwon Park, Sarah Park, Younghoon Jang, Nicholas Waring, Anup Dey, Keiko Ozato, Binbin Lai, Weiqun Peng, Kai Ge
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4a7139498fa741c093bf16e3320affb8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4a7139498fa741c093bf16e3320affb8
record_format	dspace
spelling	oai:doaj.org-article:4a7139498fa741c093bf16e3320affb82021-12-02T14:42:24ZBrd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis10.1038/s41467-017-02403-52041-1723https://doaj.org/article/4a7139498fa741c093bf16e3320affb82017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02403-5https://doaj.org/toc/2041-1723Despite being an important cancer drug target, the role of epigenetic reader Brd4 in cell differentiation and development remains unclear. Here, the authors provide evidence that Brd4 plays an important role in adipogenesis and myogenesis by binding to active enhancers to regulate gene expression.Ji-Eun LeeYoung-Kwon ParkSarah ParkYounghoon JangNicholas WaringAnup DeyKeiko OzatoBinbin LaiWeiqun PengKai GeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ji-Eun Lee Young-Kwon Park Sarah Park Younghoon Jang Nicholas Waring Anup Dey Keiko Ozato Binbin Lai Weiqun Peng Kai Ge Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis
description	Despite being an important cancer drug target, the role of epigenetic reader Brd4 in cell differentiation and development remains unclear. Here, the authors provide evidence that Brd4 plays an important role in adipogenesis and myogenesis by binding to active enhancers to regulate gene expression.
format	article
author	Ji-Eun Lee Young-Kwon Park Sarah Park Younghoon Jang Nicholas Waring Anup Dey Keiko Ozato Binbin Lai Weiqun Peng Kai Ge
author_facet	Ji-Eun Lee Young-Kwon Park Sarah Park Younghoon Jang Nicholas Waring Anup Dey Keiko Ozato Binbin Lai Weiqun Peng Kai Ge
author_sort	Ji-Eun Lee
title	Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis
title_short	Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis
title_full	Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis
title_fullStr	Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis
title_full_unstemmed	Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis
title_sort	brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4a7139498fa741c093bf16e3320affb8
work_keys_str_mv	AT jieunlee brd4bindstoactiveenhancerstocontrolcellidentitygeneinductioninadipogenesisandmyogenesis AT youngkwonpark brd4bindstoactiveenhancerstocontrolcellidentitygeneinductioninadipogenesisandmyogenesis AT sarahpark brd4bindstoactiveenhancerstocontrolcellidentitygeneinductioninadipogenesisandmyogenesis AT younghoonjang brd4bindstoactiveenhancerstocontrolcellidentitygeneinductioninadipogenesisandmyogenesis AT nicholaswaring brd4bindstoactiveenhancerstocontrolcellidentitygeneinductioninadipogenesisandmyogenesis AT anupdey brd4bindstoactiveenhancerstocontrolcellidentitygeneinductioninadipogenesisandmyogenesis AT keikoozato brd4bindstoactiveenhancerstocontrolcellidentitygeneinductioninadipogenesisandmyogenesis AT binbinlai brd4bindstoactiveenhancerstocontrolcellidentitygeneinductioninadipogenesisandmyogenesis AT weiqunpeng brd4bindstoactiveenhancerstocontrolcellidentitygeneinductioninadipogenesisandmyogenesis AT kaige brd4bindstoactiveenhancerstocontrolcellidentitygeneinductioninadipogenesisandmyogenesis
_version_	1718389686308700160

Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis

Ejemplares similares