Human Fecal Metabolome Reflects Differences in Body Mass Index, Physical Fitness, and Blood Lipoproteins in Healthy Older Adults
This study investigated how body mass index (BMI), physical fitness, and blood plasma lipoprotein levels are related to the fecal metabolome in older adults. The fecal metabolome data were acquired using proton nuclear magnetic resonance spectroscopy and gas chromatography–mass spectrometry on 163 h...
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MDPI AG
2021
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oai:doaj.org-article:4a730ccf445e46b5bee0b5d33186c0d82021-11-25T18:20:24ZHuman Fecal Metabolome Reflects Differences in Body Mass Index, Physical Fitness, and Blood Lipoproteins in Healthy Older Adults10.3390/metabo111107172218-1989https://doaj.org/article/4a730ccf445e46b5bee0b5d33186c0d82021-10-01T00:00:00Zhttps://www.mdpi.com/2218-1989/11/11/717https://doaj.org/toc/2218-1989This study investigated how body mass index (BMI), physical fitness, and blood plasma lipoprotein levels are related to the fecal metabolome in older adults. The fecal metabolome data were acquired using proton nuclear magnetic resonance spectroscopy and gas chromatography–mass spectrometry on 163 healthy older adults (65–80 years old, 80 females and 83 males). Overweight and obese subjects (BMI ≥ 27) showed higher levels of fecal amino acids (AAs) (valine, alanine, and phenylalanine) compared to normal-weight subjects (BMI ≤ 23.5). Adults classified in the high-fitness group displayed slightly lower concentrations of fecal short-chain fatty acids, propionic acid, and AAs (methionine, leucine, glutamic acid, and threonine) compared to the low-fitness group. Subjects with lower levels of cholesterol in low-density lipoprotein particles (LDL<i>chol,</i> ≤2.6 mmol/L) displayed higher fecal levels of valine, glutamic acid, phenylalanine, and lactic acid, while subjects with a higher level of cholesterol in high-density lipoprotein particles (HDL<i>chol,</i> ≥2.1 mmol/L) showed lower fecal concentration of isovaleric acid. The results from this study suggest that the human fecal metabolome, which primarily represents undigested food waste and metabolites produced by the gut microbiome, carries important information about human health and should be closely integrated to other <i>omics</i> data for a better understanding of the role of the gut microbiome and diet on human health and metabolism.Mengni CuiAlessia TrimignoJosue L. Castro-MejíaSøren ReitelsederJacob BülowRasmus Leidesdorff BechshøftDennis Sandris NielsenLars HolmSøren Balling EngelsenBekzod KhakimovMDPI AGarticlehuman fecal metabolomeBMIfitnesslipoproteins<sup>1</sup>H NMRGC-MSMicrobiologyQR1-502ENMetabolites, Vol 11, Iss 717, p 717 (2021) |
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DOAJ |
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EN |
| topic |
human fecal metabolome BMI fitness lipoproteins <sup>1</sup>H NMR GC-MS Microbiology QR1-502 |
| spellingShingle |
human fecal metabolome BMI fitness lipoproteins <sup>1</sup>H NMR GC-MS Microbiology QR1-502 Mengni Cui Alessia Trimigno Josue L. Castro-Mejía Søren Reitelseder Jacob Bülow Rasmus Leidesdorff Bechshøft Dennis Sandris Nielsen Lars Holm Søren Balling Engelsen Bekzod Khakimov Human Fecal Metabolome Reflects Differences in Body Mass Index, Physical Fitness, and Blood Lipoproteins in Healthy Older Adults |
| description |
This study investigated how body mass index (BMI), physical fitness, and blood plasma lipoprotein levels are related to the fecal metabolome in older adults. The fecal metabolome data were acquired using proton nuclear magnetic resonance spectroscopy and gas chromatography–mass spectrometry on 163 healthy older adults (65–80 years old, 80 females and 83 males). Overweight and obese subjects (BMI ≥ 27) showed higher levels of fecal amino acids (AAs) (valine, alanine, and phenylalanine) compared to normal-weight subjects (BMI ≤ 23.5). Adults classified in the high-fitness group displayed slightly lower concentrations of fecal short-chain fatty acids, propionic acid, and AAs (methionine, leucine, glutamic acid, and threonine) compared to the low-fitness group. Subjects with lower levels of cholesterol in low-density lipoprotein particles (LDL<i>chol,</i> ≤2.6 mmol/L) displayed higher fecal levels of valine, glutamic acid, phenylalanine, and lactic acid, while subjects with a higher level of cholesterol in high-density lipoprotein particles (HDL<i>chol,</i> ≥2.1 mmol/L) showed lower fecal concentration of isovaleric acid. The results from this study suggest that the human fecal metabolome, which primarily represents undigested food waste and metabolites produced by the gut microbiome, carries important information about human health and should be closely integrated to other <i>omics</i> data for a better understanding of the role of the gut microbiome and diet on human health and metabolism. |
| format |
article |
| author |
Mengni Cui Alessia Trimigno Josue L. Castro-Mejía Søren Reitelseder Jacob Bülow Rasmus Leidesdorff Bechshøft Dennis Sandris Nielsen Lars Holm Søren Balling Engelsen Bekzod Khakimov |
| author_facet |
Mengni Cui Alessia Trimigno Josue L. Castro-Mejía Søren Reitelseder Jacob Bülow Rasmus Leidesdorff Bechshøft Dennis Sandris Nielsen Lars Holm Søren Balling Engelsen Bekzod Khakimov |
| author_sort |
Mengni Cui |
| title |
Human Fecal Metabolome Reflects Differences in Body Mass Index, Physical Fitness, and Blood Lipoproteins in Healthy Older Adults |
| title_short |
Human Fecal Metabolome Reflects Differences in Body Mass Index, Physical Fitness, and Blood Lipoproteins in Healthy Older Adults |
| title_full |
Human Fecal Metabolome Reflects Differences in Body Mass Index, Physical Fitness, and Blood Lipoproteins in Healthy Older Adults |
| title_fullStr |
Human Fecal Metabolome Reflects Differences in Body Mass Index, Physical Fitness, and Blood Lipoproteins in Healthy Older Adults |
| title_full_unstemmed |
Human Fecal Metabolome Reflects Differences in Body Mass Index, Physical Fitness, and Blood Lipoproteins in Healthy Older Adults |
| title_sort |
human fecal metabolome reflects differences in body mass index, physical fitness, and blood lipoproteins in healthy older adults |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/4a730ccf445e46b5bee0b5d33186c0d8 |
| work_keys_str_mv |
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