DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification

METTL2 methyltransferase is responsible for 3-methylcytosine modification of arginine tRNAs in mammals. Here the authors show that DALR anticodon binding domain containing 3 (DALRD3) forms a complex with METTL2 to recognize specific arginine tRNAs and find DALRD3 mutations in patients with developme...

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Autores principales:	Jenna M. Lentini, Hessa S. Alsaif, Eissa Faqeih, Fowzan S. Alkuraya, Dragony Fu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4a76953347334ff0bd398da0a47580b0
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spelling	oai:doaj.org-article:4a76953347334ff0bd398da0a47580b02021-12-02T15:45:18ZDALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification10.1038/s41467-020-16321-62041-1723https://doaj.org/article/4a76953347334ff0bd398da0a47580b02020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16321-6https://doaj.org/toc/2041-1723METTL2 methyltransferase is responsible for 3-methylcytosine modification of arginine tRNAs in mammals. Here the authors show that DALR anticodon binding domain containing 3 (DALRD3) forms a complex with METTL2 to recognize specific arginine tRNAs and find DALRD3 mutations in patients with developmental delay and early-onset epileptic encephalopathy.Jenna M. LentiniHessa S. AlsaifEissa FaqeihFowzan S. AlkurayaDragony FuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jenna M. Lentini Hessa S. Alsaif Eissa Faqeih Fowzan S. Alkuraya Dragony Fu DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification
description	METTL2 methyltransferase is responsible for 3-methylcytosine modification of arginine tRNAs in mammals. Here the authors show that DALR anticodon binding domain containing 3 (DALRD3) forms a complex with METTL2 to recognize specific arginine tRNAs and find DALRD3 mutations in patients with developmental delay and early-onset epileptic encephalopathy.
format	article
author	Jenna M. Lentini Hessa S. Alsaif Eissa Faqeih Fowzan S. Alkuraya Dragony Fu
author_facet	Jenna M. Lentini Hessa S. Alsaif Eissa Faqeih Fowzan S. Alkuraya Dragony Fu
author_sort	Jenna M. Lentini
title	DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification
title_short	DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification
title_full	DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification
title_fullStr	DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification
title_full_unstemmed	DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification
title_sort	dalrd3 encodes a protein mutated in epileptic encephalopathy that targets arginine trnas for 3-methylcytosine modification
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4a76953347334ff0bd398da0a47580b0
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DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification

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