KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling

The ciliary transition zone (TZ) regulates the protein and membrane composition of the primary cilium. Here the authors identify the kinesin-3 motor protein KIF13B as a regulator of TZ membrane composition that controls the ciliary accumulation of Smoothened, which is involved in activation of Sonic...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kenneth B. Schou, Johanne B. Mogensen, Stine K. Morthorst, Brian S. Nielsen, Aiste Aleliunaite, Andrea Serra-Marques, Nicoline Fürstenberg, Sophie Saunier, Albane A. Bizet, Iben R. Veland, Anna Akhmanova, Søren T. Christensen, Lotte B. Pedersen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4a77c7802fc44747aaa6938b4cd0dde6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4a77c7802fc44747aaa6938b4cd0dde6
record_format	dspace
spelling	oai:doaj.org-article:4a77c7802fc44747aaa6938b4cd0dde62021-12-02T14:42:06ZKIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling10.1038/ncomms141772041-1723https://doaj.org/article/4a77c7802fc44747aaa6938b4cd0dde62017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14177https://doaj.org/toc/2041-1723The ciliary transition zone (TZ) regulates the protein and membrane composition of the primary cilium. Here the authors identify the kinesin-3 motor protein KIF13B as a regulator of TZ membrane composition that controls the ciliary accumulation of Smoothened, which is involved in activation of Sonic hedgehog signalling.Kenneth B. SchouJohanne B. MogensenStine K. MorthorstBrian S. NielsenAiste AleliunaiteAndrea Serra-MarquesNicoline FürstenbergSophie SaunierAlbane A. BizetIben R. VelandAnna AkhmanovaSøren T. ChristensenLotte B. PedersenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kenneth B. Schou Johanne B. Mogensen Stine K. Morthorst Brian S. Nielsen Aiste Aleliunaite Andrea Serra-Marques Nicoline Fürstenberg Sophie Saunier Albane A. Bizet Iben R. Veland Anna Akhmanova Søren T. Christensen Lotte B. Pedersen KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling
description	The ciliary transition zone (TZ) regulates the protein and membrane composition of the primary cilium. Here the authors identify the kinesin-3 motor protein KIF13B as a regulator of TZ membrane composition that controls the ciliary accumulation of Smoothened, which is involved in activation of Sonic hedgehog signalling.
format	article
author	Kenneth B. Schou Johanne B. Mogensen Stine K. Morthorst Brian S. Nielsen Aiste Aleliunaite Andrea Serra-Marques Nicoline Fürstenberg Sophie Saunier Albane A. Bizet Iben R. Veland Anna Akhmanova Søren T. Christensen Lotte B. Pedersen
author_facet	Kenneth B. Schou Johanne B. Mogensen Stine K. Morthorst Brian S. Nielsen Aiste Aleliunaite Andrea Serra-Marques Nicoline Fürstenberg Sophie Saunier Albane A. Bizet Iben R. Veland Anna Akhmanova Søren T. Christensen Lotte B. Pedersen
author_sort	Kenneth B. Schou
title	KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling
title_short	KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling
title_full	KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling
title_fullStr	KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling
title_full_unstemmed	KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling
title_sort	kif13b establishes a cav1-enriched microdomain at the ciliary transition zone to promote sonic hedgehog signalling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4a77c7802fc44747aaa6938b4cd0dde6
work_keys_str_mv	AT kennethbschou kif13bestablishesacav1enrichedmicrodomainattheciliarytransitionzonetopromotesonichedgehogsignalling AT johannebmogensen kif13bestablishesacav1enrichedmicrodomainattheciliarytransitionzonetopromotesonichedgehogsignalling AT stinekmorthorst kif13bestablishesacav1enrichedmicrodomainattheciliarytransitionzonetopromotesonichedgehogsignalling AT briansnielsen kif13bestablishesacav1enrichedmicrodomainattheciliarytransitionzonetopromotesonichedgehogsignalling AT aistealeliunaite kif13bestablishesacav1enrichedmicrodomainattheciliarytransitionzonetopromotesonichedgehogsignalling AT andreaserramarques kif13bestablishesacav1enrichedmicrodomainattheciliarytransitionzonetopromotesonichedgehogsignalling AT nicolinefurstenberg kif13bestablishesacav1enrichedmicrodomainattheciliarytransitionzonetopromotesonichedgehogsignalling AT sophiesaunier kif13bestablishesacav1enrichedmicrodomainattheciliarytransitionzonetopromotesonichedgehogsignalling AT albaneabizet kif13bestablishesacav1enrichedmicrodomainattheciliarytransitionzonetopromotesonichedgehogsignalling AT ibenrveland kif13bestablishesacav1enrichedmicrodomainattheciliarytransitionzonetopromotesonichedgehogsignalling AT annaakhmanova kif13bestablishesacav1enrichedmicrodomainattheciliarytransitionzonetopromotesonichedgehogsignalling AT sørentchristensen kif13bestablishesacav1enrichedmicrodomainattheciliarytransitionzonetopromotesonichedgehogsignalling AT lottebpedersen kif13bestablishesacav1enrichedmicrodomainattheciliarytransitionzonetopromotesonichedgehogsignalling
_version_	1718389806245871616

KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling

Ejemplares similares