Polymeric nanoparticles for targeted treatment in oncology: current insights

Rashmi H Prabhu,1 Vandana B Patravale,1 Medha D Joshi2 1Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, India; 2Department of Pharmaceutical Sciences, Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, USA Abstract: Chemotherapy,...

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Autores principales:	Prabhu RH, Patravale VB, Joshi MD
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4a784e123a584731ba87fe716ef70b24
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spelling	oai:doaj.org-article:4a784e123a584731ba87fe716ef70b242021-12-02T02:41:38ZPolymeric nanoparticles for targeted treatment in oncology: current insights1178-2013https://doaj.org/article/4a784e123a584731ba87fe716ef70b242015-02-01T00:00:00Zhttp://www.dovepress.com/polymeric-nanoparticles-for-targeted-treatment-in-oncology-current-ins-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Rashmi H Prabhu,1 Vandana B Patravale,1 Medha D Joshi2 1Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, India; 2Department of Pharmaceutical Sciences, Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, USA Abstract: Chemotherapy, a major strategy for cancer treatment, lacks the specificity to localize the cancer therapeutics in the tumor site, thereby affecting normal healthy tissues and advocating toxic adverse effects. Nanotechnological intervention has greatly revolutionized the therapy of cancer by surmounting the current limitations in conventional chemotherapy, which include undesirable biodistribution, cancer cell drug resistance, and severe systemic side effects. Nanoparticles (NPs) achieve preferential accumulation in the tumor site by virtue of their passive and ligand-based targeting mechanisms. Polymer-based nanomedicine, an arena that entails the use of polymeric NPs, polymer micelles, dendrimers, polymersomes, polyplexes, polymer–lipid hybrid systems, and polymer–drug/protein conjugates for improvement in efficacy of cancer therapeutics, has been widely explored. The broad scope for chemically modifying the polymer into desired construct makes it a versatile delivery system. Several polymer-based therapeutic NPs have been approved for clinical use. This review provides an insight into the advances in polymer-based targeted nanocarriers with focus on therapeutic aspects in the field of oncology. Keywords: polymeric nanoparticles, cancer, passive delivery, ligand-based deliveryPrabhu RHPatravale VBJoshi MDDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 1001-1018 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Prabhu RH Patravale VB Joshi MD Polymeric nanoparticles for targeted treatment in oncology: current insights
description	Rashmi H Prabhu,1 Vandana B Patravale,1 Medha D Joshi2 1Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, India; 2Department of Pharmaceutical Sciences, Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, USA Abstract: Chemotherapy, a major strategy for cancer treatment, lacks the specificity to localize the cancer therapeutics in the tumor site, thereby affecting normal healthy tissues and advocating toxic adverse effects. Nanotechnological intervention has greatly revolutionized the therapy of cancer by surmounting the current limitations in conventional chemotherapy, which include undesirable biodistribution, cancer cell drug resistance, and severe systemic side effects. Nanoparticles (NPs) achieve preferential accumulation in the tumor site by virtue of their passive and ligand-based targeting mechanisms. Polymer-based nanomedicine, an arena that entails the use of polymeric NPs, polymer micelles, dendrimers, polymersomes, polyplexes, polymer–lipid hybrid systems, and polymer–drug/protein conjugates for improvement in efficacy of cancer therapeutics, has been widely explored. The broad scope for chemically modifying the polymer into desired construct makes it a versatile delivery system. Several polymer-based therapeutic NPs have been approved for clinical use. This review provides an insight into the advances in polymer-based targeted nanocarriers with focus on therapeutic aspects in the field of oncology. Keywords: polymeric nanoparticles, cancer, passive delivery, ligand-based delivery
format	article
author	Prabhu RH Patravale VB Joshi MD
author_facet	Prabhu RH Patravale VB Joshi MD
author_sort	Prabhu RH
title	Polymeric nanoparticles for targeted treatment in oncology: current insights
title_short	Polymeric nanoparticles for targeted treatment in oncology: current insights
title_full	Polymeric nanoparticles for targeted treatment in oncology: current insights
title_fullStr	Polymeric nanoparticles for targeted treatment in oncology: current insights
title_full_unstemmed	Polymeric nanoparticles for targeted treatment in oncology: current insights
title_sort	polymeric nanoparticles for targeted treatment in oncology: current insights
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/4a784e123a584731ba87fe716ef70b24
work_keys_str_mv	AT prabhurh polymericnanoparticlesfortargetedtreatmentinoncologycurrentinsights AT patravalevb polymericnanoparticlesfortargetedtreatmentinoncologycurrentinsights AT joshimd polymericnanoparticlesfortargetedtreatmentinoncologycurrentinsights
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Polymeric nanoparticles for targeted treatment in oncology: current insights

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