1,25D3 prevents CD8+Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter

Type 2 CD8+ T cells (Tc2) play a role in the development of experimental asthma. Here the authors show that 1,25D3, the active form of vitamin D3, can prevent conversion of CD8+T cells to a Tc2 phenotype, reducing asthma susceptibility.

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Detalles Bibliográficos
Autores principales:	Michaela Schedel, Yi Jia, Sven Michel, Katsuyuki Takeda, Joanne Domenico, Anthony Joetham, Fangkun Ning, Matthew Strand, Junyan Han, Meiqin Wang, Joseph J. Lucas, Christian Vogelberg, Michael Kabesch, Brian P. O’Connor, Erwin W. Gelfand
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4a78e690244b43d29f1c6343ad4eae22
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spelling	oai:doaj.org-article:4a78e690244b43d29f1c6343ad4eae222021-12-02T17:32:08Z1,25D3 prevents CD8+Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter10.1038/ncomms102132041-1723https://doaj.org/article/4a78e690244b43d29f1c6343ad4eae222016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10213https://doaj.org/toc/2041-1723Type 2 CD8+ T cells (Tc2) play a role in the development of experimental asthma. Here the authors show that 1,25D3, the active form of vitamin D3, can prevent conversion of CD8+T cells to a Tc2 phenotype, reducing asthma susceptibility.Michaela SchedelYi JiaSven MichelKatsuyuki TakedaJoanne DomenicoAnthony JoethamFangkun NingMatthew StrandJunyan HanMeiqin WangJoseph J. LucasChristian VogelbergMichael KabeschBrian P. O’ConnorErwin W. GelfandNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michaela Schedel Yi Jia Sven Michel Katsuyuki Takeda Joanne Domenico Anthony Joetham Fangkun Ning Matthew Strand Junyan Han Meiqin Wang Joseph J. Lucas Christian Vogelberg Michael Kabesch Brian P. O’Connor Erwin W. Gelfand 1,25D3 prevents CD8+Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter
description	Type 2 CD8+ T cells (Tc2) play a role in the development of experimental asthma. Here the authors show that 1,25D3, the active form of vitamin D3, can prevent conversion of CD8+T cells to a Tc2 phenotype, reducing asthma susceptibility.
format	article
author	Michaela Schedel Yi Jia Sven Michel Katsuyuki Takeda Joanne Domenico Anthony Joetham Fangkun Ning Matthew Strand Junyan Han Meiqin Wang Joseph J. Lucas Christian Vogelberg Michael Kabesch Brian P. O’Connor Erwin W. Gelfand
author_facet	Michaela Schedel Yi Jia Sven Michel Katsuyuki Takeda Joanne Domenico Anthony Joetham Fangkun Ning Matthew Strand Junyan Han Meiqin Wang Joseph J. Lucas Christian Vogelberg Michael Kabesch Brian P. O’Connor Erwin W. Gelfand
author_sort	Michaela Schedel
title	1,25D3 prevents CD8+Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter
title_short	1,25D3 prevents CD8+Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter
title_full	1,25D3 prevents CD8+Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter
title_fullStr	1,25D3 prevents CD8+Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter
title_full_unstemmed	1,25D3 prevents CD8+Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter
title_sort	1,25d3 prevents cd8+tc2 skewing and asthma development through vdr binding changes to the cyp11a1 promoter
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4a78e690244b43d29f1c6343ad4eae22
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1,25D3 prevents CD8+Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter

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