In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties

Regulated exocytosis of neuronal synaptic vesicles is substantially faster than that of endocrine dense core vesicles despite similar molecular machineries. Here authors compare SNARE-mediated fusion of purified synaptic vesicles with insulin vesicles and see disparities in calcium-triggered fusion...

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Autores principales:	Alex J. B. Kreutzberger, Volker Kiessling, Christopher Stroupe, Binyong Liang, Julia Preobraschenski, Marcelo Ganzella, Mark A. B. Kreutzberger, Robert Nakamoto, Reinhard Jahn, J. David Castle, Lukas K. Tamm
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4a79a606ae254e35b295a19f8e1dafc2
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spelling	oai:doaj.org-article:4a79a606ae254e35b295a19f8e1dafc22021-12-02T14:38:42ZIn vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties10.1038/s41467-019-11873-82041-1723https://doaj.org/article/4a79a606ae254e35b295a19f8e1dafc22019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11873-8https://doaj.org/toc/2041-1723Regulated exocytosis of neuronal synaptic vesicles is substantially faster than that of endocrine dense core vesicles despite similar molecular machineries. Here authors compare SNARE-mediated fusion of purified synaptic vesicles with insulin vesicles and see disparities in calcium-triggered fusion rates.Alex J. B. KreutzbergerVolker KiesslingChristopher StroupeBinyong LiangJulia PreobraschenskiMarcelo GanzellaMark A. B. KreutzbergerRobert NakamotoReinhard JahnJ. David CastleLukas K. TammNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alex J. B. Kreutzberger Volker Kiessling Christopher Stroupe Binyong Liang Julia Preobraschenski Marcelo Ganzella Mark A. B. Kreutzberger Robert Nakamoto Reinhard Jahn J. David Castle Lukas K. Tamm In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties
description	Regulated exocytosis of neuronal synaptic vesicles is substantially faster than that of endocrine dense core vesicles despite similar molecular machineries. Here authors compare SNARE-mediated fusion of purified synaptic vesicles with insulin vesicles and see disparities in calcium-triggered fusion rates.
format	article
author	Alex J. B. Kreutzberger Volker Kiessling Christopher Stroupe Binyong Liang Julia Preobraschenski Marcelo Ganzella Mark A. B. Kreutzberger Robert Nakamoto Reinhard Jahn J. David Castle Lukas K. Tamm
author_facet	Alex J. B. Kreutzberger Volker Kiessling Christopher Stroupe Binyong Liang Julia Preobraschenski Marcelo Ganzella Mark A. B. Kreutzberger Robert Nakamoto Reinhard Jahn J. David Castle Lukas K. Tamm
author_sort	Alex J. B. Kreutzberger
title	In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties
title_short	In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties
title_full	In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties
title_fullStr	In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties
title_full_unstemmed	In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties
title_sort	in vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4a79a606ae254e35b295a19f8e1dafc2
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In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties

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