Comparative use of CRISPR and RNAi to modulate integrin α3β1 in triple negative breast cancer cells reveals that some pro-invasive/pro-metastatic α3β1 functions are independent of global regulation of the transcriptome.
Integrin receptors for the extracellular matrix play critical roles at all stages of carcinogenesis, including tumor growth, tumor progression and metastasis. The laminin-binding integrin α3β1 is expressed in all epithelial tissues where it has important roles in cell survival, migration, proliferat...
Guardado en:
Autores principales: | James Kenney, Abibatou Ndoye, John M Lamar, C Michael DiPersio |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/4a7ddf358a44417baa65d2017e150d81 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Molecular dynamics analysis of a novel β3 Pro189Ser mutation in a patient with glanzmann thrombasthenia differentially affecting αIIbβ3 and αvβ3 expression.
por: Michel Laguerre, et al.
Publicado: (2013) -
Modeling and molecular dynamics of HPA-1a and -1b polymorphisms: effects on the structure of the β3 subunit of the αIIbβ3 integrin.
por: Vincent Jallu, et al.
Publicado: (2012) -
αvβ3 Integrin induces partial EMT independent of TGF-β signaling
por: Yoshinobu Kariya, et al.
Publicado: (2021) -
αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin
por: Mitasha Bharadwaj, et al.
Publicado: (2017) -
The integrin-linked kinase-PINCH-parvin complex supports integrin αIIbβ3 activation.
por: Shigenori Honda, et al.
Publicado: (2013)