Enhanced anti-cancer activity of andrographis with oligomeric proanthocyanidins through activation of metabolic and ferroptosis pathways in colorectal cancer

Abstract The high degree of morbidity and mortality in colorectal cancer (CRC) patients is largely due to the development of chemoresistance against conventional chemotherapeutic drugs. In view of the accumulating evidence that various dietary botanicals offer a safe, inexpensive and multi-targeted...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tadanobu Shimura, Priyanka Sharma, Geeta G. Sharma, Jasjit K. Banwait, Ajay Goel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4a82efb76e0e40579a53168c121554d8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4a82efb76e0e40579a53168c121554d8
record_format	dspace
spelling	oai:doaj.org-article:4a82efb76e0e40579a53168c121554d82021-12-02T14:17:19ZEnhanced anti-cancer activity of andrographis with oligomeric proanthocyanidins through activation of metabolic and ferroptosis pathways in colorectal cancer10.1038/s41598-021-87283-y2045-2322https://doaj.org/article/4a82efb76e0e40579a53168c121554d82021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87283-yhttps://doaj.org/toc/2045-2322Abstract The high degree of morbidity and mortality in colorectal cancer (CRC) patients is largely due to the development of chemoresistance against conventional chemotherapeutic drugs. In view of the accumulating evidence that various dietary botanicals offer a safe, inexpensive and multi-targeted treatment option, herein, we hypothesized that a combination of Andrographis paniculata and Oligomeric Proanthocyanidins (OPCs) might interact together with regard to anti-tumorigenic activity in CRC. As a result, we demonstrated the enhanced anti-cancer activity between these two botanical extracts in terms of their ability to inhibit cancer cell growth, suppress colony formation and induce apoptosis. Furthermore, we validated these findings in subcutaneous xenograft model and in patient derived primary epithelial 3D organoids. Transcriptomic profiling identified involvement of metabolic pathways and ferroptosis-associated genes, including HMOX1, GCLC and GCLM, that may be responsible for the increased anti-tumorigenic activity by the two compounds. Collectively, our study provides novel evidence in support of the combinatorial use of andrographis and OPCs as a potential therapeutic option, perhaps as an adjunctive treatment to classical drugs, in patients with colorectal cancer.Tadanobu ShimuraPriyanka SharmaGeeta G. SharmaJasjit K. BanwaitAjay GoelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tadanobu Shimura Priyanka Sharma Geeta G. Sharma Jasjit K. Banwait Ajay Goel Enhanced anti-cancer activity of andrographis with oligomeric proanthocyanidins through activation of metabolic and ferroptosis pathways in colorectal cancer
description	Abstract The high degree of morbidity and mortality in colorectal cancer (CRC) patients is largely due to the development of chemoresistance against conventional chemotherapeutic drugs. In view of the accumulating evidence that various dietary botanicals offer a safe, inexpensive and multi-targeted treatment option, herein, we hypothesized that a combination of Andrographis paniculata and Oligomeric Proanthocyanidins (OPCs) might interact together with regard to anti-tumorigenic activity in CRC. As a result, we demonstrated the enhanced anti-cancer activity between these two botanical extracts in terms of their ability to inhibit cancer cell growth, suppress colony formation and induce apoptosis. Furthermore, we validated these findings in subcutaneous xenograft model and in patient derived primary epithelial 3D organoids. Transcriptomic profiling identified involvement of metabolic pathways and ferroptosis-associated genes, including HMOX1, GCLC and GCLM, that may be responsible for the increased anti-tumorigenic activity by the two compounds. Collectively, our study provides novel evidence in support of the combinatorial use of andrographis and OPCs as a potential therapeutic option, perhaps as an adjunctive treatment to classical drugs, in patients with colorectal cancer.
format	article
author	Tadanobu Shimura Priyanka Sharma Geeta G. Sharma Jasjit K. Banwait Ajay Goel
author_facet	Tadanobu Shimura Priyanka Sharma Geeta G. Sharma Jasjit K. Banwait Ajay Goel
author_sort	Tadanobu Shimura
title	Enhanced anti-cancer activity of andrographis with oligomeric proanthocyanidins through activation of metabolic and ferroptosis pathways in colorectal cancer
title_short	Enhanced anti-cancer activity of andrographis with oligomeric proanthocyanidins through activation of metabolic and ferroptosis pathways in colorectal cancer
title_full	Enhanced anti-cancer activity of andrographis with oligomeric proanthocyanidins through activation of metabolic and ferroptosis pathways in colorectal cancer
title_fullStr	Enhanced anti-cancer activity of andrographis with oligomeric proanthocyanidins through activation of metabolic and ferroptosis pathways in colorectal cancer
title_full_unstemmed	Enhanced anti-cancer activity of andrographis with oligomeric proanthocyanidins through activation of metabolic and ferroptosis pathways in colorectal cancer
title_sort	enhanced anti-cancer activity of andrographis with oligomeric proanthocyanidins through activation of metabolic and ferroptosis pathways in colorectal cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4a82efb76e0e40579a53168c121554d8
work_keys_str_mv	AT tadanobushimura enhancedanticanceractivityofandrographiswitholigomericproanthocyanidinsthroughactivationofmetabolicandferroptosispathwaysincolorectalcancer AT priyankasharma enhancedanticanceractivityofandrographiswitholigomericproanthocyanidinsthroughactivationofmetabolicandferroptosispathwaysincolorectalcancer AT geetagsharma enhancedanticanceractivityofandrographiswitholigomericproanthocyanidinsthroughactivationofmetabolicandferroptosispathwaysincolorectalcancer AT jasjitkbanwait enhancedanticanceractivityofandrographiswitholigomericproanthocyanidinsthroughactivationofmetabolicandferroptosispathwaysincolorectalcancer AT ajaygoel enhancedanticanceractivityofandrographiswitholigomericproanthocyanidinsthroughactivationofmetabolicandferroptosispathwaysincolorectalcancer
_version_	1718391603791396864

Enhanced anti-cancer activity of andrographis with oligomeric proanthocyanidins through activation of metabolic and ferroptosis pathways in colorectal cancer

Ejemplares similares