Pre-Clinical Models in Implant Dentistry: Past, Present, Future

Biomedical research seeks to generate experimental results for translation to clinical settings. In order to improve the transition from bench to bedside, researchers must draw justifiable conclusions based on data from an appropriate model. Animal testing, as a prerequisite to human clinical exposu...

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Autores principales:	Nicolas Blanc-Sylvestre, Philippe Bouchard, Catherine Chaussain, Claire Bardet
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	pre-clinical research murine dental implant human-sized dental implant osseointegration biocompatibility implant models Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4a84c330c1c24ff9925a39102df696b3
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spelling	oai:doaj.org-article:4a84c330c1c24ff9925a39102df696b32021-11-25T16:48:41ZPre-Clinical Models in Implant Dentistry: Past, Present, Future10.3390/biomedicines91115382227-9059https://doaj.org/article/4a84c330c1c24ff9925a39102df696b32021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1538https://doaj.org/toc/2227-9059Biomedical research seeks to generate experimental results for translation to clinical settings. In order to improve the transition from bench to bedside, researchers must draw justifiable conclusions based on data from an appropriate model. Animal testing, as a prerequisite to human clinical exposure, is performed in a range of species, from laboratory mice to larger animals (such as dogs or non-human primates). Minipigs appear to be the animal of choice for studying bone surgery around intraoral dental implants. Dog models, well-known in the field of dental implant research, tend now to be used for studies conducted under compromised oral conditions (biofilm). Regarding small animal models, research studies mostly use rodents, with interest in rabbit models declining. Mouse models remain a reference for genetic studies. On the other hand, over the last decade, scientific advances and government guidelines have led to the replacement, reduction, and refinement of the use of all animal models in dental implant research. In new development strategies, some in vivo experiments are being progressively replaced by in vitro or biomaterial approaches. In this review, we summarize the key information on the animal models currently available for dental implant research and highlight (i) the pros and cons of each type, (ii) new levels of decisional procedures regarding study objectives, and (iii) the outlook for animal research, discussing possible non-animal options.Nicolas Blanc-SylvestrePhilippe BouchardCatherine ChaussainClaire BardetMDPI AGarticlepre-clinical researchmurine dental implanthuman-sized dental implantosseointegrationbiocompatibilityimplant modelsBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1538, p 1538 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pre-clinical research murine dental implant human-sized dental implant osseointegration biocompatibility implant models Biology (General) QH301-705.5
spellingShingle	pre-clinical research murine dental implant human-sized dental implant osseointegration biocompatibility implant models Biology (General) QH301-705.5 Nicolas Blanc-Sylvestre Philippe Bouchard Catherine Chaussain Claire Bardet Pre-Clinical Models in Implant Dentistry: Past, Present, Future
description	Biomedical research seeks to generate experimental results for translation to clinical settings. In order to improve the transition from bench to bedside, researchers must draw justifiable conclusions based on data from an appropriate model. Animal testing, as a prerequisite to human clinical exposure, is performed in a range of species, from laboratory mice to larger animals (such as dogs or non-human primates). Minipigs appear to be the animal of choice for studying bone surgery around intraoral dental implants. Dog models, well-known in the field of dental implant research, tend now to be used for studies conducted under compromised oral conditions (biofilm). Regarding small animal models, research studies mostly use rodents, with interest in rabbit models declining. Mouse models remain a reference for genetic studies. On the other hand, over the last decade, scientific advances and government guidelines have led to the replacement, reduction, and refinement of the use of all animal models in dental implant research. In new development strategies, some in vivo experiments are being progressively replaced by in vitro or biomaterial approaches. In this review, we summarize the key information on the animal models currently available for dental implant research and highlight (i) the pros and cons of each type, (ii) new levels of decisional procedures regarding study objectives, and (iii) the outlook for animal research, discussing possible non-animal options.
format	article
author	Nicolas Blanc-Sylvestre Philippe Bouchard Catherine Chaussain Claire Bardet
author_facet	Nicolas Blanc-Sylvestre Philippe Bouchard Catherine Chaussain Claire Bardet
author_sort	Nicolas Blanc-Sylvestre
title	Pre-Clinical Models in Implant Dentistry: Past, Present, Future
title_short	Pre-Clinical Models in Implant Dentistry: Past, Present, Future
title_full	Pre-Clinical Models in Implant Dentistry: Past, Present, Future
title_fullStr	Pre-Clinical Models in Implant Dentistry: Past, Present, Future
title_full_unstemmed	Pre-Clinical Models in Implant Dentistry: Past, Present, Future
title_sort	pre-clinical models in implant dentistry: past, present, future
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4a84c330c1c24ff9925a39102df696b3
work_keys_str_mv	AT nicolasblancsylvestre preclinicalmodelsinimplantdentistrypastpresentfuture AT philippebouchard preclinicalmodelsinimplantdentistrypastpresentfuture AT catherinechaussain preclinicalmodelsinimplantdentistrypastpresentfuture AT clairebardet preclinicalmodelsinimplantdentistrypastpresentfuture
_version_	1718412952147591168

Pre-Clinical Models in Implant Dentistry: Past, Present, Future

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