Pars Plana Vitrectomy for Full-Thickness Macular Holes in Patients with Proliferative Diabetic Retinopathy and Active Fibrovascular Proliferation

Mushfig Karimov, Lala Akhundova, Tarlan Aliyeva Department of Diabetic Eye Diseases, National Centre of Ophthalmology Named After Acad. Zarifa Aliyeva, Baku, AzerbaijanCorrespondence: Lala AkhundovaDepartment of Diabetic Eye Diseases, National Centre of Ophthalmology Named After Acad. Zarifa Aliyeva...

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Autores principales:	Karimov M, Akhundova L, Aliyeva T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	pars plana vitrectomy with ilm peeling tractional retinal detachment residual subretinal fluid optical coherence tomography macular hole proliferative diabetic retinopathy Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/4a8704e9df194a589e8835e7ffbb13a6
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spelling	oai:doaj.org-article:4a8704e9df194a589e8835e7ffbb13a62021-12-02T12:16:38ZPars Plana Vitrectomy for Full-Thickness Macular Holes in Patients with Proliferative Diabetic Retinopathy and Active Fibrovascular Proliferation1177-5483https://doaj.org/article/4a8704e9df194a589e8835e7ffbb13a62020-12-01T00:00:00Zhttps://www.dovepress.com/pars-plana-vitrectomy-for-full-thickness-macular-holes-in-patients-wit-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Mushfig Karimov, Lala Akhundova, Tarlan Aliyeva Department of Diabetic Eye Diseases, National Centre of Ophthalmology Named After Acad. Zarifa Aliyeva, Baku, AzerbaijanCorrespondence: Lala AkhundovaDepartment of Diabetic Eye Diseases, National Centre of Ophthalmology Named After Acad. Zarifa Aliyeva, Baku, AzerbaijanTel +994 50-3565181Email akhundova.lale@gmail.comPurpose of the Study: To study preoperative and postoperative optical coherence tomography features and the outcomes of pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling for full-thickness macular holes (MHs) associated with proliferative diabetic retinopathy.Methods: The data from 14 eyes of 11 patients with full-thickness macular holes and active diabetic fibrovascular proliferation (FVP) with/without tractional retinal detachment who underwent pars plana vitrectomy and standard ILM peeling at Zarifa Aliyeva National Ophthalmology Centre in Baku were analysed. Bilateral surgery for diabetic MHs was performed in 27.3% of patients. The minimum follow-up duration was 6 months.Results: All eyes (100%) achieved type 1 macular hole closure, with residual macular subretinal fluid (SRF) present in 13 cases after surgery (92.9%). The SRF resolved gradually without any interventions. The incidence of SRF was 92.9% at 1 month, 85.7% at 3 months, 50% at 6 months, and 14.3% at 9 months (Cochran’s Q test, χ 2 (4) =37.44, p< 0.001). Visual acuity improved after surgery in 13 cases (92.9%), with a mean difference of 0.75 ± 0.71 LogMAR between the preoperative and final values, rs=0.608, 95% BCa CI [0.037– 0.969], p=0.021.Conclusion: The standard ILM peeling technique for full-thickness MHs in eyes with active diabetic fibrovascular proliferation can help restore the anatomy and function of the macula in diabetic patients. Close follow-up is important for unilateral cases. Residual SRF in the perifoveal area is detectable by OCT after surgery in patients with macular holes associated with diabetic tractional retinal detachment, and it usually resorbs gradually without any interventions.Keywords: pars plana vitrectomy with ILM peeling, tractional retinal detachment, residual subretinal fluid, optical coherence tomography, macular hole, proliferative diabetic retinopathyKarimov MAkhundova LAliyeva TDove Medical Pressarticlepars plana vitrectomy with ilm peelingtractional retinal detachmentresidual subretinal fluidoptical coherence tomographymacular holeproliferative diabetic retinopathyOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 4125-4133 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	pars plana vitrectomy with ilm peeling tractional retinal detachment residual subretinal fluid optical coherence tomography macular hole proliferative diabetic retinopathy Ophthalmology RE1-994
spellingShingle	pars plana vitrectomy with ilm peeling tractional retinal detachment residual subretinal fluid optical coherence tomography macular hole proliferative diabetic retinopathy Ophthalmology RE1-994 Karimov M Akhundova L Aliyeva T Pars Plana Vitrectomy for Full-Thickness Macular Holes in Patients with Proliferative Diabetic Retinopathy and Active Fibrovascular Proliferation
description	Mushfig Karimov, Lala Akhundova, Tarlan Aliyeva Department of Diabetic Eye Diseases, National Centre of Ophthalmology Named After Acad. Zarifa Aliyeva, Baku, AzerbaijanCorrespondence: Lala AkhundovaDepartment of Diabetic Eye Diseases, National Centre of Ophthalmology Named After Acad. Zarifa Aliyeva, Baku, AzerbaijanTel +994 50-3565181Email akhundova.lale@gmail.comPurpose of the Study: To study preoperative and postoperative optical coherence tomography features and the outcomes of pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling for full-thickness macular holes (MHs) associated with proliferative diabetic retinopathy.Methods: The data from 14 eyes of 11 patients with full-thickness macular holes and active diabetic fibrovascular proliferation (FVP) with/without tractional retinal detachment who underwent pars plana vitrectomy and standard ILM peeling at Zarifa Aliyeva National Ophthalmology Centre in Baku were analysed. Bilateral surgery for diabetic MHs was performed in 27.3% of patients. The minimum follow-up duration was 6 months.Results: All eyes (100%) achieved type 1 macular hole closure, with residual macular subretinal fluid (SRF) present in 13 cases after surgery (92.9%). The SRF resolved gradually without any interventions. The incidence of SRF was 92.9% at 1 month, 85.7% at 3 months, 50% at 6 months, and 14.3% at 9 months (Cochran’s Q test, χ 2 (4) =37.44, p< 0.001). Visual acuity improved after surgery in 13 cases (92.9%), with a mean difference of 0.75 ± 0.71 LogMAR between the preoperative and final values, rs=0.608, 95% BCa CI [0.037– 0.969], p=0.021.Conclusion: The standard ILM peeling technique for full-thickness MHs in eyes with active diabetic fibrovascular proliferation can help restore the anatomy and function of the macula in diabetic patients. Close follow-up is important for unilateral cases. Residual SRF in the perifoveal area is detectable by OCT after surgery in patients with macular holes associated with diabetic tractional retinal detachment, and it usually resorbs gradually without any interventions.Keywords: pars plana vitrectomy with ILM peeling, tractional retinal detachment, residual subretinal fluid, optical coherence tomography, macular hole, proliferative diabetic retinopathy
format	article
author	Karimov M Akhundova L Aliyeva T
author_facet	Karimov M Akhundova L Aliyeva T
author_sort	Karimov M
title	Pars Plana Vitrectomy for Full-Thickness Macular Holes in Patients with Proliferative Diabetic Retinopathy and Active Fibrovascular Proliferation
title_short	Pars Plana Vitrectomy for Full-Thickness Macular Holes in Patients with Proliferative Diabetic Retinopathy and Active Fibrovascular Proliferation
title_full	Pars Plana Vitrectomy for Full-Thickness Macular Holes in Patients with Proliferative Diabetic Retinopathy and Active Fibrovascular Proliferation
title_fullStr	Pars Plana Vitrectomy for Full-Thickness Macular Holes in Patients with Proliferative Diabetic Retinopathy and Active Fibrovascular Proliferation
title_full_unstemmed	Pars Plana Vitrectomy for Full-Thickness Macular Holes in Patients with Proliferative Diabetic Retinopathy and Active Fibrovascular Proliferation
title_sort	pars plana vitrectomy for full-thickness macular holes in patients with proliferative diabetic retinopathy and active fibrovascular proliferation
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/4a8704e9df194a589e8835e7ffbb13a6
work_keys_str_mv	AT karimovm parsplanavitrectomyforfullthicknessmacularholesinpatientswithproliferativediabeticretinopathyandactivefibrovascularproliferation AT akhundoval parsplanavitrectomyforfullthicknessmacularholesinpatientswithproliferativediabeticretinopathyandactivefibrovascularproliferation AT aliyevat parsplanavitrectomyforfullthicknessmacularholesinpatientswithproliferativediabeticretinopathyandactivefibrovascularproliferation
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Pars Plana Vitrectomy for Full-Thickness Macular Holes in Patients with Proliferative Diabetic Retinopathy and Active Fibrovascular Proliferation

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