Adults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study

Abstract Higher mortality in asthmatics has been shown previously. However, evidence on different asthma phenotypes on long-term mortality risk is limited. The aim was to evaluate the impact of asthma phenotypes on mortality in general population. Data from the National Health and Nutrition Examinat...

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Autores principales:	Xumei He, GeSheng Cheng, Lu He, Bing Liao, YaJuan Du, Xuegang Xie, Songlin Zhang, Gang Li, Yafeng Wang, YuShun Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4a87903c350c42b0b13abd94bfe9b78d
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spelling	oai:doaj.org-article:4a87903c350c42b0b13abd94bfe9b78d2021-12-02T15:23:07ZAdults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study10.1038/s41598-020-79264-42045-2322https://doaj.org/article/4a87903c350c42b0b13abd94bfe9b78d2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79264-4https://doaj.org/toc/2045-2322Abstract Higher mortality in asthmatics has been shown previously. However, evidence on different asthma phenotypes on long-term mortality risk is limited. The aim was to evaluate the impact of asthma phenotypes on mortality in general population. Data from the National Health and Nutrition Examination Survey from 2001–2002 to 2013–2014 linked mortality files through December 31, 2015, were used (N = 37,015). Cox proportional hazards regression was used to estimate the risk of all-cause and cause-specific mortality adjusting for sociodemographic characteristics, smoking, body mass index, and chronic conditions. During the mean follow-up time of 7.5 years, 4326 participants died from a variety of causes. Current asthma, but not former asthma was associated with increased all-cause mortality (current asthma: HR = 1.37; 95% CI 1.20–1.58; Former asthma: HR = 0.93; 95% CI 0.73–1.18); as well as mortality from cardiovascular disease (HRCurrent = 1.41; 95% CI 1.08–1.85) and chronic lower respiratory diseases (HRCurrent = 3.17; 95% CI 1.96–5.14). In addition, we found that the HR for cardiovascular disease (CVD) mortality was slightly greater in people with childhood-onset asthma than those with adult-onset asthma. The HR for chronic lower respiratory diseases (CLRD) mortality was greater in people with adult-onset asthma than those with childhood-onset asthma. However, the differences were not statistically significant. Our study suggested that current asthma but not former asthma was associated with increased all-cause, CLRD and CVD mortality. Future well-designed studies with larger sample are required to demonstrate the association and clarify the potential mechanisms involved.Xumei HeGeSheng ChengLu HeBing LiaoYaJuan DuXuegang XieSonglin ZhangGang LiYafeng WangYuShun ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xumei He GeSheng Cheng Lu He Bing Liao YaJuan Du Xuegang Xie Songlin Zhang Gang Li Yafeng Wang YuShun Zhang Adults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study
description	Abstract Higher mortality in asthmatics has been shown previously. However, evidence on different asthma phenotypes on long-term mortality risk is limited. The aim was to evaluate the impact of asthma phenotypes on mortality in general population. Data from the National Health and Nutrition Examination Survey from 2001–2002 to 2013–2014 linked mortality files through December 31, 2015, were used (N = 37,015). Cox proportional hazards regression was used to estimate the risk of all-cause and cause-specific mortality adjusting for sociodemographic characteristics, smoking, body mass index, and chronic conditions. During the mean follow-up time of 7.5 years, 4326 participants died from a variety of causes. Current asthma, but not former asthma was associated with increased all-cause mortality (current asthma: HR = 1.37; 95% CI 1.20–1.58; Former asthma: HR = 0.93; 95% CI 0.73–1.18); as well as mortality from cardiovascular disease (HRCurrent = 1.41; 95% CI 1.08–1.85) and chronic lower respiratory diseases (HRCurrent = 3.17; 95% CI 1.96–5.14). In addition, we found that the HR for cardiovascular disease (CVD) mortality was slightly greater in people with childhood-onset asthma than those with adult-onset asthma. The HR for chronic lower respiratory diseases (CLRD) mortality was greater in people with adult-onset asthma than those with childhood-onset asthma. However, the differences were not statistically significant. Our study suggested that current asthma but not former asthma was associated with increased all-cause, CLRD and CVD mortality. Future well-designed studies with larger sample are required to demonstrate the association and clarify the potential mechanisms involved.
format	article
author	Xumei He GeSheng Cheng Lu He Bing Liao YaJuan Du Xuegang Xie Songlin Zhang Gang Li Yafeng Wang YuShun Zhang
author_facet	Xumei He GeSheng Cheng Lu He Bing Liao YaJuan Du Xuegang Xie Songlin Zhang Gang Li Yafeng Wang YuShun Zhang
author_sort	Xumei He
title	Adults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study
title_short	Adults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study
title_full	Adults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study
title_fullStr	Adults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study
title_full_unstemmed	Adults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study
title_sort	adults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4a87903c350c42b0b13abd94bfe9b78d
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Adults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study

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