DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates

Podosomes are protrusive structures that coordinate diverse functions related to cell invasion, migration, bone resorption and immune surveillance. Here the authors integrate DNA nanotechnology with FLIM-FRET to demonstrate that podosomes apply pN integrin tensile forces to sense and respond to subs...

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Autores principales: Roxanne Glazier, Joshua M. Brockman, Emily Bartle, Alexa L. Mattheyses, Olivier Destaing, Khalid Salaita
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/4a8b99e9937f47cb9e52b7240832a5e8
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