Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion

Double strand breaks (DSBs) are preferentially repaired by sister-chromatid recombination (SCR) to maintain genome stability. Here, the authors reveal a role for histone deacetylate (HDAC) complexes favouring the repair of replication related DSBs by facilitating cohesin loading.

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Detalles Bibliográficos
Autores principales: Pedro Ortega, Belén Gómez-González, Andrés Aguilera
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/4a8ce01633054664a0436cc1b2c2bbf1
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Descripción
Sumario:Double strand breaks (DSBs) are preferentially repaired by sister-chromatid recombination (SCR) to maintain genome stability. Here, the authors reveal a role for histone deacetylate (HDAC) complexes favouring the repair of replication related DSBs by facilitating cohesin loading.