Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion

Double strand breaks (DSBs) are preferentially repaired by sister-chromatid recombination (SCR) to maintain genome stability. Here, the authors reveal a role for histone deacetylate (HDAC) complexes favouring the repair of replication related DSBs by facilitating cohesin loading.

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Autores principales:	Pedro Ortega, Belén Gómez-González, Andrés Aguilera
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4a8ce01633054664a0436cc1b2c2bbf1
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spelling	oai:doaj.org-article:4a8ce01633054664a0436cc1b2c2bbf12021-12-02T15:36:24ZRpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion10.1038/s41467-019-13210-52041-1723https://doaj.org/article/4a8ce01633054664a0436cc1b2c2bbf12019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13210-5https://doaj.org/toc/2041-1723Double strand breaks (DSBs) are preferentially repaired by sister-chromatid recombination (SCR) to maintain genome stability. Here, the authors reveal a role for histone deacetylate (HDAC) complexes favouring the repair of replication related DSBs by facilitating cohesin loading.Pedro OrtegaBelén Gómez-GonzálezAndrés AguileraNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pedro Ortega Belén Gómez-González Andrés Aguilera Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion
description	Double strand breaks (DSBs) are preferentially repaired by sister-chromatid recombination (SCR) to maintain genome stability. Here, the authors reveal a role for histone deacetylate (HDAC) complexes favouring the repair of replication related DSBs by facilitating cohesin loading.
format	article
author	Pedro Ortega Belén Gómez-González Andrés Aguilera
author_facet	Pedro Ortega Belén Gómez-González Andrés Aguilera
author_sort	Pedro Ortega
title	Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion
title_short	Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion
title_full	Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion
title_fullStr	Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion
title_full_unstemmed	Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion
title_sort	rpd3l and hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4a8ce01633054664a0436cc1b2c2bbf1
work_keys_str_mv	AT pedroortega rpd3landhda1histonedeacetylasesfacilitaterepairofbrokenforksbypromotingsisterchromatidcohesion AT belengomezgonzalez rpd3landhda1histonedeacetylasesfacilitaterepairofbrokenforksbypromotingsisterchromatidcohesion AT andresaguilera rpd3landhda1histonedeacetylasesfacilitaterepairofbrokenforksbypromotingsisterchromatidcohesion
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Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion

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