Human islets contain four distinct subtypes of β cells
Dysfunction or loss of insulin-secreting β cells in the pancreas is a hallmark of diabetes. Here, Dorrell et al.identify four subpopulations of β cells in humans, which differ in gene expression and insulin secretion kinetics, and the abundance of which is altered in patients with type 2 diabetes.
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Nature Portfolio
2016
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oai:doaj.org-article:4a8e221047c74cf29f151b27d212cf852021-12-02T16:50:14ZHuman islets contain four distinct subtypes of β cells10.1038/ncomms117562041-1723https://doaj.org/article/4a8e221047c74cf29f151b27d212cf852016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms11756https://doaj.org/toc/2041-1723Dysfunction or loss of insulin-secreting β cells in the pancreas is a hallmark of diabetes. Here, Dorrell et al.identify four subpopulations of β cells in humans, which differ in gene expression and insulin secretion kinetics, and the abundance of which is altered in patients with type 2 diabetes.Craig DorrellJonathan SchugPamela S. CanadayHolger A. RussBranden D. TarlowMaria T. GrompeTamara HortonMatthias HebrokPhilip R. StreeterKlaus H. KaestnerMarkus GrompeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Craig Dorrell Jonathan Schug Pamela S. Canaday Holger A. Russ Branden D. Tarlow Maria T. Grompe Tamara Horton Matthias Hebrok Philip R. Streeter Klaus H. Kaestner Markus Grompe Human islets contain four distinct subtypes of β cells |
| description |
Dysfunction or loss of insulin-secreting β cells in the pancreas is a hallmark of diabetes. Here, Dorrell et al.identify four subpopulations of β cells in humans, which differ in gene expression and insulin secretion kinetics, and the abundance of which is altered in patients with type 2 diabetes. |
| format |
article |
| author |
Craig Dorrell Jonathan Schug Pamela S. Canaday Holger A. Russ Branden D. Tarlow Maria T. Grompe Tamara Horton Matthias Hebrok Philip R. Streeter Klaus H. Kaestner Markus Grompe |
| author_facet |
Craig Dorrell Jonathan Schug Pamela S. Canaday Holger A. Russ Branden D. Tarlow Maria T. Grompe Tamara Horton Matthias Hebrok Philip R. Streeter Klaus H. Kaestner Markus Grompe |
| author_sort |
Craig Dorrell |
| title |
Human islets contain four distinct subtypes of β cells |
| title_short |
Human islets contain four distinct subtypes of β cells |
| title_full |
Human islets contain four distinct subtypes of β cells |
| title_fullStr |
Human islets contain four distinct subtypes of β cells |
| title_full_unstemmed |
Human islets contain four distinct subtypes of β cells |
| title_sort |
human islets contain four distinct subtypes of β cells |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/4a8e221047c74cf29f151b27d212cf85 |
| work_keys_str_mv |
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