Dual Contrast - Magnetic Resonance Fingerprinting (DC-MRF): A Platform for Simultaneous Quantification of Multiple MRI Contrast Agents

Abstract Injectable Magnetic Resonance Imaging (MRI) contrast agents have been widely used to provide critical assessments of disease for both clinical and basic science imaging research studies. The scope of available MRI contrast agents has expanded over the years with the emergence of molecular i...

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Autores principales:	Christian E. Anderson, Shannon B. Donnola, Yun Jiang, Joshua Batesole, Rebecca Darrah, Mitchell L. Drumm, Susann M. Brady-Kalnay, Nicole F. Steinmetz, Xin Yu, Mark A. Griswold, Chris A. Flask
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4a950a2595b44f11a9e01dfa43686cfc
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spelling	oai:doaj.org-article:4a950a2595b44f11a9e01dfa43686cfc2021-12-02T11:52:37ZDual Contrast - Magnetic Resonance Fingerprinting (DC-MRF): A Platform for Simultaneous Quantification of Multiple MRI Contrast Agents10.1038/s41598-017-08762-92045-2322https://doaj.org/article/4a950a2595b44f11a9e01dfa43686cfc2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08762-9https://doaj.org/toc/2045-2322Abstract Injectable Magnetic Resonance Imaging (MRI) contrast agents have been widely used to provide critical assessments of disease for both clinical and basic science imaging research studies. The scope of available MRI contrast agents has expanded over the years with the emergence of molecular imaging contrast agents specifically targeted to biological markers. Unfortunately, synergistic application of more than a single molecular contrast agent has been limited by MRI’s ability to only dynamically measure a single agent at a time. In this study, a new Dual Contrast - Magnetic Resonance Fingerprinting (DC – MRF) methodology is described that can detect and independently quantify the local concentration of multiple MRI contrast agents following simultaneous administration. This “multi-color” MRI methodology provides the opportunity to monitor multiple molecular species simultaneously and provides a practical, quantitative imaging framework for the eventual clinical translation of molecular imaging contrast agents.Christian E. AndersonShannon B. DonnolaYun JiangJoshua BatesoleRebecca DarrahMitchell L. DrummSusann M. Brady-KalnayNicole F. SteinmetzXin YuMark A. GriswoldChris A. FlaskNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christian E. Anderson Shannon B. Donnola Yun Jiang Joshua Batesole Rebecca Darrah Mitchell L. Drumm Susann M. Brady-Kalnay Nicole F. Steinmetz Xin Yu Mark A. Griswold Chris A. Flask Dual Contrast - Magnetic Resonance Fingerprinting (DC-MRF): A Platform for Simultaneous Quantification of Multiple MRI Contrast Agents
description	Abstract Injectable Magnetic Resonance Imaging (MRI) contrast agents have been widely used to provide critical assessments of disease for both clinical and basic science imaging research studies. The scope of available MRI contrast agents has expanded over the years with the emergence of molecular imaging contrast agents specifically targeted to biological markers. Unfortunately, synergistic application of more than a single molecular contrast agent has been limited by MRI’s ability to only dynamically measure a single agent at a time. In this study, a new Dual Contrast - Magnetic Resonance Fingerprinting (DC – MRF) methodology is described that can detect and independently quantify the local concentration of multiple MRI contrast agents following simultaneous administration. This “multi-color” MRI methodology provides the opportunity to monitor multiple molecular species simultaneously and provides a practical, quantitative imaging framework for the eventual clinical translation of molecular imaging contrast agents.
format	article
author	Christian E. Anderson Shannon B. Donnola Yun Jiang Joshua Batesole Rebecca Darrah Mitchell L. Drumm Susann M. Brady-Kalnay Nicole F. Steinmetz Xin Yu Mark A. Griswold Chris A. Flask
author_facet	Christian E. Anderson Shannon B. Donnola Yun Jiang Joshua Batesole Rebecca Darrah Mitchell L. Drumm Susann M. Brady-Kalnay Nicole F. Steinmetz Xin Yu Mark A. Griswold Chris A. Flask
author_sort	Christian E. Anderson
title	Dual Contrast - Magnetic Resonance Fingerprinting (DC-MRF): A Platform for Simultaneous Quantification of Multiple MRI Contrast Agents
title_short	Dual Contrast - Magnetic Resonance Fingerprinting (DC-MRF): A Platform for Simultaneous Quantification of Multiple MRI Contrast Agents
title_full	Dual Contrast - Magnetic Resonance Fingerprinting (DC-MRF): A Platform for Simultaneous Quantification of Multiple MRI Contrast Agents
title_fullStr	Dual Contrast - Magnetic Resonance Fingerprinting (DC-MRF): A Platform for Simultaneous Quantification of Multiple MRI Contrast Agents
title_full_unstemmed	Dual Contrast - Magnetic Resonance Fingerprinting (DC-MRF): A Platform for Simultaneous Quantification of Multiple MRI Contrast Agents
title_sort	dual contrast - magnetic resonance fingerprinting (dc-mrf): a platform for simultaneous quantification of multiple mri contrast agents
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4a950a2595b44f11a9e01dfa43686cfc
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Dual Contrast - Magnetic Resonance Fingerprinting (DC-MRF): A Platform for Simultaneous Quantification of Multiple MRI Contrast Agents

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