Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance

PGC-1α is activated by exercise and promotes resistance to fatigue in muscles. Here, the authors show that PGC-1α activates the malate-aspartate shuttle, and allows muscle to utilise kynurenine, leading to more efficient glucose oxidation and mitochondrial respiration.

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Autores principales:	Leandro Z. Agudelo, Duarte M. S. Ferreira, Shamim Dadvar, Igor Cervenka, Lars Ketscher, Manizheh Izadi, Liu Zhengye, Regula Furrer, Christoph Handschin, Tomas Venckunas, Marius Brazaitis, Sigitas Kamandulis, Johanna T. Lanner, Jorge L. Ruas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4a97fef9ea204ae2827332216ca511a8
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spelling	oai:doaj.org-article:4a97fef9ea204ae2827332216ca511a82021-12-02T14:39:19ZSkeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance10.1038/s41467-019-10712-02041-1723https://doaj.org/article/4a97fef9ea204ae2827332216ca511a82019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10712-0https://doaj.org/toc/2041-1723PGC-1α is activated by exercise and promotes resistance to fatigue in muscles. Here, the authors show that PGC-1α activates the malate-aspartate shuttle, and allows muscle to utilise kynurenine, leading to more efficient glucose oxidation and mitochondrial respiration.Leandro Z. AgudeloDuarte M. S. FerreiraShamim DadvarIgor CervenkaLars KetscherManizheh IzadiLiu ZhengyeRegula FurrerChristoph HandschinTomas VenckunasMarius BrazaitisSigitas KamandulisJohanna T. LannerJorge L. RuasNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Leandro Z. Agudelo Duarte M. S. Ferreira Shamim Dadvar Igor Cervenka Lars Ketscher Manizheh Izadi Liu Zhengye Regula Furrer Christoph Handschin Tomas Venckunas Marius Brazaitis Sigitas Kamandulis Johanna T. Lanner Jorge L. Ruas Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance
description	PGC-1α is activated by exercise and promotes resistance to fatigue in muscles. Here, the authors show that PGC-1α activates the malate-aspartate shuttle, and allows muscle to utilise kynurenine, leading to more efficient glucose oxidation and mitochondrial respiration.
format	article
author	Leandro Z. Agudelo Duarte M. S. Ferreira Shamim Dadvar Igor Cervenka Lars Ketscher Manizheh Izadi Liu Zhengye Regula Furrer Christoph Handschin Tomas Venckunas Marius Brazaitis Sigitas Kamandulis Johanna T. Lanner Jorge L. Ruas
author_facet	Leandro Z. Agudelo Duarte M. S. Ferreira Shamim Dadvar Igor Cervenka Lars Ketscher Manizheh Izadi Liu Zhengye Regula Furrer Christoph Handschin Tomas Venckunas Marius Brazaitis Sigitas Kamandulis Johanna T. Lanner Jorge L. Ruas
author_sort	Leandro Z. Agudelo
title	Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance
title_short	Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance
title_full	Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance
title_fullStr	Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance
title_full_unstemmed	Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance
title_sort	skeletal muscle pgc-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4a97fef9ea204ae2827332216ca511a8
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Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance

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