Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis

Kidney stone disease is caused by accumulation of oxalate crystals, which trigger tissue injury, inflammation and cell death. Mulay et al. show that crystals induce cell death in the kidney through necroptosis, and propose that this pathway may be a target for the treatment of crystal-induced diseas...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shrikant R. Mulay, Jyaysi Desai, Santhosh V. Kumar, Jonathan N. Eberhard, Dana Thomasova, Simone Romoli, Melissa Grigorescu, Onkar P. Kulkarni, Bastian Popper, Volker Vielhauer, Gabriele Zuchtriegel, Christoph Reichel, Jan Hinrich Bräsen, Paola Romagnani, Rostyslav Bilyy, Luis E. Munoz, Martin Herrmann, Helen Liapis, Stefan Krautwald, Andreas Linkermann, Hans-Joachim Anders
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4a9913da2de547b6b63c6e14c5eae1e2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4a9913da2de547b6b63c6e14c5eae1e2
record_format	dspace
spelling	oai:doaj.org-article:4a9913da2de547b6b63c6e14c5eae1e22021-12-02T17:33:21ZCytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis10.1038/ncomms102742041-1723https://doaj.org/article/4a9913da2de547b6b63c6e14c5eae1e22016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10274https://doaj.org/toc/2041-1723Kidney stone disease is caused by accumulation of oxalate crystals, which trigger tissue injury, inflammation and cell death. Mulay et al. show that crystals induce cell death in the kidney through necroptosis, and propose that this pathway may be a target for the treatment of crystal-induced disease.Shrikant R. MulayJyaysi DesaiSanthosh V. KumarJonathan N. EberhardDana ThomasovaSimone RomoliMelissa GrigorescuOnkar P. KulkarniBastian PopperVolker VielhauerGabriele ZuchtriegelChristoph ReichelJan Hinrich BräsenPaola RomagnaniRostyslav BilyyLuis E. MunozMartin HerrmannHelen LiapisStefan KrautwaldAndreas LinkermannHans-Joachim AndersNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shrikant R. Mulay Jyaysi Desai Santhosh V. Kumar Jonathan N. Eberhard Dana Thomasova Simone Romoli Melissa Grigorescu Onkar P. Kulkarni Bastian Popper Volker Vielhauer Gabriele Zuchtriegel Christoph Reichel Jan Hinrich Bräsen Paola Romagnani Rostyslav Bilyy Luis E. Munoz Martin Herrmann Helen Liapis Stefan Krautwald Andreas Linkermann Hans-Joachim Anders Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis
description	Kidney stone disease is caused by accumulation of oxalate crystals, which trigger tissue injury, inflammation and cell death. Mulay et al. show that crystals induce cell death in the kidney through necroptosis, and propose that this pathway may be a target for the treatment of crystal-induced disease.
format	article
author	Shrikant R. Mulay Jyaysi Desai Santhosh V. Kumar Jonathan N. Eberhard Dana Thomasova Simone Romoli Melissa Grigorescu Onkar P. Kulkarni Bastian Popper Volker Vielhauer Gabriele Zuchtriegel Christoph Reichel Jan Hinrich Bräsen Paola Romagnani Rostyslav Bilyy Luis E. Munoz Martin Herrmann Helen Liapis Stefan Krautwald Andreas Linkermann Hans-Joachim Anders
author_facet	Shrikant R. Mulay Jyaysi Desai Santhosh V. Kumar Jonathan N. Eberhard Dana Thomasova Simone Romoli Melissa Grigorescu Onkar P. Kulkarni Bastian Popper Volker Vielhauer Gabriele Zuchtriegel Christoph Reichel Jan Hinrich Bräsen Paola Romagnani Rostyslav Bilyy Luis E. Munoz Martin Herrmann Helen Liapis Stefan Krautwald Andreas Linkermann Hans-Joachim Anders
author_sort	Shrikant R. Mulay
title	Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis
title_short	Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis
title_full	Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis
title_fullStr	Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis
title_full_unstemmed	Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis
title_sort	cytotoxicity of crystals involves ripk3-mlkl-mediated necroptosis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4a9913da2de547b6b63c6e14c5eae1e2
work_keys_str_mv	AT shrikantrmulay cytotoxicityofcrystalsinvolvesripk3mlklmediatednecroptosis AT jyaysidesai cytotoxicityofcrystalsinvolvesripk3mlklmediatednecroptosis AT santhoshvkumar cytotoxicityofcrystalsinvolvesripk3mlklmediatednecroptosis AT jonathanneberhard cytotoxicityofcrystalsinvolvesripk3mlklmediatednecroptosis AT danathomasova cytotoxicityofcrystalsinvolvesripk3mlklmediatednecroptosis AT simoneromoli cytotoxicityofcrystalsinvolvesripk3mlklmediatednecroptosis AT melissagrigorescu cytotoxicityofcrystalsinvolvesripk3mlklmediatednecroptosis AT onkarpkulkarni cytotoxicityofcrystalsinvolvesripk3mlklmediatednecroptosis AT bastianpopper cytotoxicityofcrystalsinvolvesripk3mlklmediatednecroptosis AT volkervielhauer cytotoxicityofcrystalsinvolvesripk3mlklmediatednecroptosis AT gabrielezuchtriegel cytotoxicityofcrystalsinvolvesripk3mlklmediatednecroptosis AT christophreichel cytotoxicityofcrystalsinvolvesripk3mlklmediatednecroptosis AT janhinrichbrasen cytotoxicityofcrystalsinvolvesripk3mlklmediatednecroptosis AT paolaromagnani cytotoxicityofcrystalsinvolvesripk3mlklmediatednecroptosis AT rostyslavbilyy cytotoxicityofcrystalsinvolvesripk3mlklmediatednecroptosis AT luisemunoz cytotoxicityofcrystalsinvolvesripk3mlklmediatednecroptosis AT martinherrmann cytotoxicityofcrystalsinvolvesripk3mlklmediatednecroptosis AT helenliapis cytotoxicityofcrystalsinvolvesripk3mlklmediatednecroptosis AT stefankrautwald cytotoxicityofcrystalsinvolvesripk3mlklmediatednecroptosis AT andreaslinkermann cytotoxicityofcrystalsinvolvesripk3mlklmediatednecroptosis AT hansjoachimanders cytotoxicityofcrystalsinvolvesripk3mlklmediatednecroptosis
_version_	1718379937470087168

Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis

Ejemplares similares