Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype

Tumour-associated macrophages (TAMs) display an M2 phenotype that promote tumour immune escape. Here the authors show that Chloroquine (CQ), a lysosome inhibitor used against malaria, inhibits tumour growth by switching TAMs into an M1 tumor-killing phenotype by repolarizing macrophages metabolism.

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Autores principales:	Degao Chen, Jing Xie, Roland Fiskesund, Wenqian Dong, Xiaoyu Liang, Jiadi Lv, Xun Jin, Jinyan Liu, Siqi Mo, Tianzhen Zhang, Feiran Cheng, Yabo Zhou, Huafeng Zhang, Ke Tang, Jingwei Ma, Yuying Liu, Bo Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4a9c4b1511e545f59e2bd49d27a475dc
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spelling	oai:doaj.org-article:4a9c4b1511e545f59e2bd49d27a475dc2021-12-02T14:41:28ZChloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype10.1038/s41467-018-03225-92041-1723https://doaj.org/article/4a9c4b1511e545f59e2bd49d27a475dc2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03225-9https://doaj.org/toc/2041-1723Tumour-associated macrophages (TAMs) display an M2 phenotype that promote tumour immune escape. Here the authors show that Chloroquine (CQ), a lysosome inhibitor used against malaria, inhibits tumour growth by switching TAMs into an M1 tumor-killing phenotype by repolarizing macrophages metabolism.Degao ChenJing XieRoland FiskesundWenqian DongXiaoyu LiangJiadi LvXun JinJinyan LiuSiqi MoTianzhen ZhangFeiran ChengYabo ZhouHuafeng ZhangKe TangJingwei MaYuying LiuBo HuangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Degao Chen Jing Xie Roland Fiskesund Wenqian Dong Xiaoyu Liang Jiadi Lv Xun Jin Jinyan Liu Siqi Mo Tianzhen Zhang Feiran Cheng Yabo Zhou Huafeng Zhang Ke Tang Jingwei Ma Yuying Liu Bo Huang Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype
description	Tumour-associated macrophages (TAMs) display an M2 phenotype that promote tumour immune escape. Here the authors show that Chloroquine (CQ), a lysosome inhibitor used against malaria, inhibits tumour growth by switching TAMs into an M1 tumor-killing phenotype by repolarizing macrophages metabolism.
format	article
author	Degao Chen Jing Xie Roland Fiskesund Wenqian Dong Xiaoyu Liang Jiadi Lv Xun Jin Jinyan Liu Siqi Mo Tianzhen Zhang Feiran Cheng Yabo Zhou Huafeng Zhang Ke Tang Jingwei Ma Yuying Liu Bo Huang
author_facet	Degao Chen Jing Xie Roland Fiskesund Wenqian Dong Xiaoyu Liang Jiadi Lv Xun Jin Jinyan Liu Siqi Mo Tianzhen Zhang Feiran Cheng Yabo Zhou Huafeng Zhang Ke Tang Jingwei Ma Yuying Liu Bo Huang
author_sort	Degao Chen
title	Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype
title_short	Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype
title_full	Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype
title_fullStr	Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype
title_full_unstemmed	Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype
title_sort	chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward m1 phenotype
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4a9c4b1511e545f59e2bd49d27a475dc
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Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype

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