Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype
Tumour-associated macrophages (TAMs) display an M2 phenotype that promote tumour immune escape. Here the authors show that Chloroquine (CQ), a lysosome inhibitor used against malaria, inhibits tumour growth by switching TAMs into an M1 tumor-killing phenotype by repolarizing macrophages metabolism.
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2018
|
| Subjects: | |
| Online Access: | https://doaj.org/article/4a9c4b1511e545f59e2bd49d27a475dc |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Be the first to leave a comment!