Genomic and immune profiling of pre-invasive lung adenocarcinoma

Genomic and immune profiling of pre-invasive lung adenocarcinoma

The genomic and immune landscape of pre-invasive lung adenocarcinoma is poorly understood. Here, the authors perform exome and transcriptome sequencing on precursor legions and invasive lung adenocarcinomas, identifying recurrently mutated genes in pre/minimally invasive cases, and arm level alterat...

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Main Authors: Haiquan Chen, Jian Carrot-Zhang, Yue Zhao, Haichuan Hu, Samuel S. Freeman, Su Yu, Gavin Ha, Alison M. Taylor, Ashton C. Berger, Lindsay Westlake, Yuanting Zheng, Jiyang Zhang, Aruna Ramachandran, Qiang Zheng, Yunjian Pan, Difan Zheng, Shanbo Zheng, Chao Cheng, Muyu Kuang, Xiaoyan Zhou, Yang Zhang, Hang Li, Ting Ye, Yuan Ma, Zhendong Gao, Xiaoting Tao, Han Han, Jun Shang, Ying Yu, Ding Bao, Yechao Huang, Xiangnan Li, Yawei Zhang, Jiaqing Xiang, Yihua Sun, Yuan Li, Andrew D. Cherniack, Joshua D. Campbell, Leming Shi, Matthew Meyerson
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/4a9c53d05b3d4f2bb8b67fc34b59ad6c
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Summary:The genomic and immune landscape of pre-invasive lung adenocarcinoma is poorly understood. Here, the authors perform exome and transcriptome sequencing on precursor legions and invasive lung adenocarcinomas, identifying recurrently mutated genes in pre/minimally invasive cases, and arm level alteration events linked to immune infiltration.

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