Genomic and immune profiling of pre-invasive lung adenocarcinoma
The genomic and immune landscape of pre-invasive lung adenocarcinoma is poorly understood. Here, the authors perform exome and transcriptome sequencing on precursor legions and invasive lung adenocarcinomas, identifying recurrently mutated genes in pre/minimally invasive cases, and arm level alterat...
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Nature Portfolio
2019
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oai:doaj.org-article:4a9c53d05b3d4f2bb8b67fc34b59ad6c2021-12-02T17:31:36ZGenomic and immune profiling of pre-invasive lung adenocarcinoma10.1038/s41467-019-13460-32041-1723https://doaj.org/article/4a9c53d05b3d4f2bb8b67fc34b59ad6c2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13460-3https://doaj.org/toc/2041-1723The genomic and immune landscape of pre-invasive lung adenocarcinoma is poorly understood. Here, the authors perform exome and transcriptome sequencing on precursor legions and invasive lung adenocarcinomas, identifying recurrently mutated genes in pre/minimally invasive cases, and arm level alteration events linked to immune infiltration.Haiquan ChenJian Carrot-ZhangYue ZhaoHaichuan HuSamuel S. FreemanSu YuGavin HaAlison M. TaylorAshton C. BergerLindsay WestlakeYuanting ZhengJiyang ZhangAruna RamachandranQiang ZhengYunjian PanDifan ZhengShanbo ZhengChao ChengMuyu KuangXiaoyan ZhouYang ZhangHang LiTing YeYuan MaZhendong GaoXiaoting TaoHan HanJun ShangYing YuDing BaoYechao HuangXiangnan LiYawei ZhangJiaqing XiangYihua SunYuan LiAndrew D. CherniackJoshua D. CampbellLeming ShiMatthew MeyersonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-6 (2019) |
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DOAJ |
| language |
EN |
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Science Q |
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Science Q Haiquan Chen Jian Carrot-Zhang Yue Zhao Haichuan Hu Samuel S. Freeman Su Yu Gavin Ha Alison M. Taylor Ashton C. Berger Lindsay Westlake Yuanting Zheng Jiyang Zhang Aruna Ramachandran Qiang Zheng Yunjian Pan Difan Zheng Shanbo Zheng Chao Cheng Muyu Kuang Xiaoyan Zhou Yang Zhang Hang Li Ting Ye Yuan Ma Zhendong Gao Xiaoting Tao Han Han Jun Shang Ying Yu Ding Bao Yechao Huang Xiangnan Li Yawei Zhang Jiaqing Xiang Yihua Sun Yuan Li Andrew D. Cherniack Joshua D. Campbell Leming Shi Matthew Meyerson Genomic and immune profiling of pre-invasive lung adenocarcinoma |
| description |
The genomic and immune landscape of pre-invasive lung adenocarcinoma is poorly understood. Here, the authors perform exome and transcriptome sequencing on precursor legions and invasive lung adenocarcinomas, identifying recurrently mutated genes in pre/minimally invasive cases, and arm level alteration events linked to immune infiltration. |
| format |
article |
| author |
Haiquan Chen Jian Carrot-Zhang Yue Zhao Haichuan Hu Samuel S. Freeman Su Yu Gavin Ha Alison M. Taylor Ashton C. Berger Lindsay Westlake Yuanting Zheng Jiyang Zhang Aruna Ramachandran Qiang Zheng Yunjian Pan Difan Zheng Shanbo Zheng Chao Cheng Muyu Kuang Xiaoyan Zhou Yang Zhang Hang Li Ting Ye Yuan Ma Zhendong Gao Xiaoting Tao Han Han Jun Shang Ying Yu Ding Bao Yechao Huang Xiangnan Li Yawei Zhang Jiaqing Xiang Yihua Sun Yuan Li Andrew D. Cherniack Joshua D. Campbell Leming Shi Matthew Meyerson |
| author_facet |
Haiquan Chen Jian Carrot-Zhang Yue Zhao Haichuan Hu Samuel S. Freeman Su Yu Gavin Ha Alison M. Taylor Ashton C. Berger Lindsay Westlake Yuanting Zheng Jiyang Zhang Aruna Ramachandran Qiang Zheng Yunjian Pan Difan Zheng Shanbo Zheng Chao Cheng Muyu Kuang Xiaoyan Zhou Yang Zhang Hang Li Ting Ye Yuan Ma Zhendong Gao Xiaoting Tao Han Han Jun Shang Ying Yu Ding Bao Yechao Huang Xiangnan Li Yawei Zhang Jiaqing Xiang Yihua Sun Yuan Li Andrew D. Cherniack Joshua D. Campbell Leming Shi Matthew Meyerson |
| author_sort |
Haiquan Chen |
| title |
Genomic and immune profiling of pre-invasive lung adenocarcinoma |
| title_short |
Genomic and immune profiling of pre-invasive lung adenocarcinoma |
| title_full |
Genomic and immune profiling of pre-invasive lung adenocarcinoma |
| title_fullStr |
Genomic and immune profiling of pre-invasive lung adenocarcinoma |
| title_full_unstemmed |
Genomic and immune profiling of pre-invasive lung adenocarcinoma |
| title_sort |
genomic and immune profiling of pre-invasive lung adenocarcinoma |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/4a9c53d05b3d4f2bb8b67fc34b59ad6c |
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