Osteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression

Abstract Orthodontic tooth movement is achieved by the remodeling of the alveolar bone surrounding roots of teeth. Upon the application of orthodontic force, osteoclastic bone resorption occurs on the compression side of alveolar bone, towards which the teeth are driven. However, the molecular basis...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ayumi Shoji-Matsunaga, Takehito Ono, Mikihito Hayashi, Hiroshi Takayanagi, Keiji Moriyama, Tomoki Nakashima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4a9c73f4cfed481480672fecbdd1aa70
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4a9c73f4cfed481480672fecbdd1aa70
record_format	dspace
spelling	oai:doaj.org-article:4a9c73f4cfed481480672fecbdd1aa702021-12-02T11:40:31ZOsteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression10.1038/s41598-017-09326-72045-2322https://doaj.org/article/4a9c73f4cfed481480672fecbdd1aa702017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09326-7https://doaj.org/toc/2045-2322Abstract Orthodontic tooth movement is achieved by the remodeling of the alveolar bone surrounding roots of teeth. Upon the application of orthodontic force, osteoclastic bone resorption occurs on the compression side of alveolar bone, towards which the teeth are driven. However, the molecular basis for the regulatory mechanisms underlying alveolar bone remodeling has not been sufficiently elucidated. Osteoclastogenesis is regulated by receptor activator of nuclear factor-κB ligand (RANKL), which is postulated to be expressed by the cells surrounding the tooth roots. Here, we show that osteocytes are the critical source of RANKL in alveolar bone remodeling during orthodontic tooth movement. Using a newly established method for the isolation of periodontal tissue component cells from alveolar bone, we found that osteocytes expressed a much higher amount of RANKL than other cells did in periodontal tissue. The critical role of osteocyte-derived RANKL was confirmed by the reduction of orthodontic tooth movement in mice specifically lacking RANKL in osteocytes. Thus, we provide in vivo evidence for the key role of osteocyte-derived RANKL in alveolar bone remodeling, establishing a molecular basis for orthodontic force-mediated bone resorption.Ayumi Shoji-MatsunagaTakehito OnoMikihito HayashiHiroshi TakayanagiKeiji MoriyamaTomoki NakashimaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ayumi Shoji-Matsunaga Takehito Ono Mikihito Hayashi Hiroshi Takayanagi Keiji Moriyama Tomoki Nakashima Osteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression
description	Abstract Orthodontic tooth movement is achieved by the remodeling of the alveolar bone surrounding roots of teeth. Upon the application of orthodontic force, osteoclastic bone resorption occurs on the compression side of alveolar bone, towards which the teeth are driven. However, the molecular basis for the regulatory mechanisms underlying alveolar bone remodeling has not been sufficiently elucidated. Osteoclastogenesis is regulated by receptor activator of nuclear factor-κB ligand (RANKL), which is postulated to be expressed by the cells surrounding the tooth roots. Here, we show that osteocytes are the critical source of RANKL in alveolar bone remodeling during orthodontic tooth movement. Using a newly established method for the isolation of periodontal tissue component cells from alveolar bone, we found that osteocytes expressed a much higher amount of RANKL than other cells did in periodontal tissue. The critical role of osteocyte-derived RANKL was confirmed by the reduction of orthodontic tooth movement in mice specifically lacking RANKL in osteocytes. Thus, we provide in vivo evidence for the key role of osteocyte-derived RANKL in alveolar bone remodeling, establishing a molecular basis for orthodontic force-mediated bone resorption.
format	article
author	Ayumi Shoji-Matsunaga Takehito Ono Mikihito Hayashi Hiroshi Takayanagi Keiji Moriyama Tomoki Nakashima
author_facet	Ayumi Shoji-Matsunaga Takehito Ono Mikihito Hayashi Hiroshi Takayanagi Keiji Moriyama Tomoki Nakashima
author_sort	Ayumi Shoji-Matsunaga
title	Osteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression
title_short	Osteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression
title_full	Osteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression
title_fullStr	Osteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression
title_full_unstemmed	Osteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression
title_sort	osteocyte regulation of orthodontic force-mediated tooth movement via rankl expression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4a9c73f4cfed481480672fecbdd1aa70
work_keys_str_mv	AT ayumishojimatsunaga osteocyteregulationoforthodonticforcemediatedtoothmovementviaranklexpression AT takehitoono osteocyteregulationoforthodonticforcemediatedtoothmovementviaranklexpression AT mikihitohayashi osteocyteregulationoforthodonticforcemediatedtoothmovementviaranklexpression AT hiroshitakayanagi osteocyteregulationoforthodonticforcemediatedtoothmovementviaranklexpression AT keijimoriyama osteocyteregulationoforthodonticforcemediatedtoothmovementviaranklexpression AT tomokinakashima osteocyteregulationoforthodonticforcemediatedtoothmovementviaranklexpression
_version_	1718395579455766528

Osteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression

Ejemplares similares