Gestational and lactational exposure to BPA, but not BPS, negatively impacts trabecular microarchitecture and cortical geometry in adult male offspring

Bisphenol-A (BPA) and bisphenol-S (BPS) are endocrine disrupting chemicals (EDCs) found primarily in plastics. Estrogen is a primary hormonal regulator of skeletal growth and development; however, the impact of gestational BPA or BPS exposure on skeletal health of offspring remains relatively unknow...

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Autores principales:	Rebecca K. Dirkes, Rebecca J. Welly, Jiude Mao, Jessica Kinkade, Victoria J. Vieira-Potter, Cheryl S. Rosenfeld, Pamela S. Bruzina
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Bisphenols Gestation Biomechanical strength Skeletal development Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/4a9f002806064812a1d9f8452f2c6dd4
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spelling	oai:doaj.org-article:4a9f002806064812a1d9f8452f2c6dd42021-11-14T04:33:28ZGestational and lactational exposure to BPA, but not BPS, negatively impacts trabecular microarchitecture and cortical geometry in adult male offspring2352-187210.1016/j.bonr.2021.101147https://doaj.org/article/4a9f002806064812a1d9f8452f2c6dd42021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352187221004046https://doaj.org/toc/2352-1872Bisphenol-A (BPA) and bisphenol-S (BPS) are endocrine disrupting chemicals (EDCs) found primarily in plastics. Estrogen is a primary hormonal regulator of skeletal growth and development; however, the impact of gestational BPA or BPS exposure on skeletal health of offspring remains relatively unknown. Here, adult female mice were randomized into three treatment groups: 200 μg BPA/kg BW (BPA), 200 μg BPS/kg BW (BPS) or control (CON). Animals were then further randomized to exercising (EX) or sedentary (SED) groups. Treatment continued through mating, gestation, and lactation. One male offspring from each dam (n = 6–8/group) was assessed at 16 weeks of age to evaluate effects of EDC exposure on the adult skeleton. Cortical geometry of the mid-diaphysis and trabecular microarchitecture of the distal femur were assessed via micro-CT. Biomechanical strength and mineral apposition rate of the femoral diaphysis were assessed via three-point bending and dynamic histomorphometry, respectively. Two-factor ANOVA or ANCOVA were used to determine the effects of maternal EX and BPA or BPS on trabecular and cortical bone outcomes. Maternal EX led to a significant decrease in body fat percentage and bone stiffness, independent of EDC exposure. Offspring exposed to BPA had significantly lower trabecular bone volume, trabecular number, connectivity density, cortical thickness, and greater trabecular spacing compared to BPS or CON animals. In conclusion, gestational BPA, but not BPS, exposure negatively impacted trabecular microarchitecture and cortical geometry in adult male offspring. If these findings translate to humans, this could have significant public health impacts on expecting women or those seeking to become pregnant.Rebecca K. DirkesRebecca J. WellyJiude MaoJessica KinkadeVictoria J. Vieira-PotterCheryl S. RosenfeldPamela S. BruzinaElsevierarticleBisphenolsGestationBiomechanical strengthSkeletal developmentDiseases of the musculoskeletal systemRC925-935ENBone Reports, Vol 15, Iss , Pp 101147- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bisphenols Gestation Biomechanical strength Skeletal development Diseases of the musculoskeletal system RC925-935
spellingShingle	Bisphenols Gestation Biomechanical strength Skeletal development Diseases of the musculoskeletal system RC925-935 Rebecca K. Dirkes Rebecca J. Welly Jiude Mao Jessica Kinkade Victoria J. Vieira-Potter Cheryl S. Rosenfeld Pamela S. Bruzina Gestational and lactational exposure to BPA, but not BPS, negatively impacts trabecular microarchitecture and cortical geometry in adult male offspring
description	Bisphenol-A (BPA) and bisphenol-S (BPS) are endocrine disrupting chemicals (EDCs) found primarily in plastics. Estrogen is a primary hormonal regulator of skeletal growth and development; however, the impact of gestational BPA or BPS exposure on skeletal health of offspring remains relatively unknown. Here, adult female mice were randomized into three treatment groups: 200 μg BPA/kg BW (BPA), 200 μg BPS/kg BW (BPS) or control (CON). Animals were then further randomized to exercising (EX) or sedentary (SED) groups. Treatment continued through mating, gestation, and lactation. One male offspring from each dam (n = 6–8/group) was assessed at 16 weeks of age to evaluate effects of EDC exposure on the adult skeleton. Cortical geometry of the mid-diaphysis and trabecular microarchitecture of the distal femur were assessed via micro-CT. Biomechanical strength and mineral apposition rate of the femoral diaphysis were assessed via three-point bending and dynamic histomorphometry, respectively. Two-factor ANOVA or ANCOVA were used to determine the effects of maternal EX and BPA or BPS on trabecular and cortical bone outcomes. Maternal EX led to a significant decrease in body fat percentage and bone stiffness, independent of EDC exposure. Offspring exposed to BPA had significantly lower trabecular bone volume, trabecular number, connectivity density, cortical thickness, and greater trabecular spacing compared to BPS or CON animals. In conclusion, gestational BPA, but not BPS, exposure negatively impacted trabecular microarchitecture and cortical geometry in adult male offspring. If these findings translate to humans, this could have significant public health impacts on expecting women or those seeking to become pregnant.
format	article
author	Rebecca K. Dirkes Rebecca J. Welly Jiude Mao Jessica Kinkade Victoria J. Vieira-Potter Cheryl S. Rosenfeld Pamela S. Bruzina
author_facet	Rebecca K. Dirkes Rebecca J. Welly Jiude Mao Jessica Kinkade Victoria J. Vieira-Potter Cheryl S. Rosenfeld Pamela S. Bruzina
author_sort	Rebecca K. Dirkes
title	Gestational and lactational exposure to BPA, but not BPS, negatively impacts trabecular microarchitecture and cortical geometry in adult male offspring
title_short	Gestational and lactational exposure to BPA, but not BPS, negatively impacts trabecular microarchitecture and cortical geometry in adult male offspring
title_full	Gestational and lactational exposure to BPA, but not BPS, negatively impacts trabecular microarchitecture and cortical geometry in adult male offspring
title_fullStr	Gestational and lactational exposure to BPA, but not BPS, negatively impacts trabecular microarchitecture and cortical geometry in adult male offspring
title_full_unstemmed	Gestational and lactational exposure to BPA, but not BPS, negatively impacts trabecular microarchitecture and cortical geometry in adult male offspring
title_sort	gestational and lactational exposure to bpa, but not bps, negatively impacts trabecular microarchitecture and cortical geometry in adult male offspring
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/4a9f002806064812a1d9f8452f2c6dd4
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Gestational and lactational exposure to BPA, but not BPS, negatively impacts trabecular microarchitecture and cortical geometry in adult male offspring

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