Analysis of the potential inappropriate use of medications in pediatric outpatients in China

Abstract Background The appropriate use of medications is essential in children. Yet, detailed information on how drugs are being prescribed and dispensed to pediatric populations is not documented in China. Aim The study objective was to analyze the details of medicine use and categorize the types...

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Autores principales:	Jing Cui, Lei Zhao, Xianghong Liu, Mengyujie Liu, Lihong Zhong
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Prescription Pediatric Outpatient Drug utilization Inappropriate medicine use Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/4a9f73eeadbf433da414158da8c13d77
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spelling	oai:doaj.org-article:4a9f73eeadbf433da414158da8c13d772021-11-28T12:07:40ZAnalysis of the potential inappropriate use of medications in pediatric outpatients in China10.1186/s12913-021-07300-81472-6963https://doaj.org/article/4a9f73eeadbf433da414158da8c13d772021-11-01T00:00:00Zhttps://doi.org/10.1186/s12913-021-07300-8https://doaj.org/toc/1472-6963Abstract Background The appropriate use of medications is essential in children. Yet, detailed information on how drugs are being prescribed and dispensed to pediatric populations is not documented in China. Aim The study objective was to analyze the details of medicine use and categorize the types of inappropriate use of medications on children. Methods A retrospective cross-sectional study was conducted on the prescriptions of pediatric outpatients aged < 18 years from 2019 to 2020 at a major Chinese tertiary academic center. Each age group’s demographic and clinical characteristics were collected, and the ratios of inappropriate prescriptions were analyzed. Results The total number of pediatric outpatients was 652,152, and 49.37% (322000) were prescribed medications, in which the most widely used medicines were respiratory, anti-infectives, and Traditional Chinese Medicines (TCMs). The prevalence rate of inappropriate prescriptions reached 20.49%, and in 2019 it was higher (21.71%) than that in 2020 (18.36%). The top three common inappropriate categories were indication-related off-label drug use, improper administration frequency, and overdosing, accounting for 67.93, 17.80 and 11.06% of all inappropriate prescriptions, respectively. The inappropriate prescriptions were more likely seen in patients aged 2–5 years and respiratory medicines. Conclusions The study findings indicate that inappropriate drug use in pediatric outpatients is still common, and great attention needs to be paid. More prospective trials are required to identify the effectiveness, safety, and necessity of off-label drug use of medicines in children.Jing CuiLei ZhaoXianghong LiuMengyujie LiuLihong ZhongBMCarticlePrescriptionPediatricOutpatientDrug utilizationInappropriate medicine usePublic aspects of medicineRA1-1270ENBMC Health Services Research, Vol 21, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Prescription Pediatric Outpatient Drug utilization Inappropriate medicine use Public aspects of medicine RA1-1270
spellingShingle	Prescription Pediatric Outpatient Drug utilization Inappropriate medicine use Public aspects of medicine RA1-1270 Jing Cui Lei Zhao Xianghong Liu Mengyujie Liu Lihong Zhong Analysis of the potential inappropriate use of medications in pediatric outpatients in China
description	Abstract Background The appropriate use of medications is essential in children. Yet, detailed information on how drugs are being prescribed and dispensed to pediatric populations is not documented in China. Aim The study objective was to analyze the details of medicine use and categorize the types of inappropriate use of medications on children. Methods A retrospective cross-sectional study was conducted on the prescriptions of pediatric outpatients aged < 18 years from 2019 to 2020 at a major Chinese tertiary academic center. Each age group’s demographic and clinical characteristics were collected, and the ratios of inappropriate prescriptions were analyzed. Results The total number of pediatric outpatients was 652,152, and 49.37% (322000) were prescribed medications, in which the most widely used medicines were respiratory, anti-infectives, and Traditional Chinese Medicines (TCMs). The prevalence rate of inappropriate prescriptions reached 20.49%, and in 2019 it was higher (21.71%) than that in 2020 (18.36%). The top three common inappropriate categories were indication-related off-label drug use, improper administration frequency, and overdosing, accounting for 67.93, 17.80 and 11.06% of all inappropriate prescriptions, respectively. The inappropriate prescriptions were more likely seen in patients aged 2–5 years and respiratory medicines. Conclusions The study findings indicate that inappropriate drug use in pediatric outpatients is still common, and great attention needs to be paid. More prospective trials are required to identify the effectiveness, safety, and necessity of off-label drug use of medicines in children.
format	article
author	Jing Cui Lei Zhao Xianghong Liu Mengyujie Liu Lihong Zhong
author_facet	Jing Cui Lei Zhao Xianghong Liu Mengyujie Liu Lihong Zhong
author_sort	Jing Cui
title	Analysis of the potential inappropriate use of medications in pediatric outpatients in China
title_short	Analysis of the potential inappropriate use of medications in pediatric outpatients in China
title_full	Analysis of the potential inappropriate use of medications in pediatric outpatients in China
title_fullStr	Analysis of the potential inappropriate use of medications in pediatric outpatients in China
title_full_unstemmed	Analysis of the potential inappropriate use of medications in pediatric outpatients in China
title_sort	analysis of the potential inappropriate use of medications in pediatric outpatients in china
publisher	BMC
publishDate	2021
url	https://doaj.org/article/4a9f73eeadbf433da414158da8c13d77
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Analysis of the potential inappropriate use of medications in pediatric outpatients in China

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